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Candidemia among Hospitalized Pediatric Patients Caused by Several Clonal Lineages of Candida parapsilosis
is the second most common cause of candidemia in some geographical areas and in children in particular. Yet, the proportion among children varies, for example, from 10.4% in Denmark to 24.7% in Tehran, Iran. As this species is also known to cause hospital outbreaks, we explored if the relatively hig...
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| Published in: | Journal of fungi (Basel) 2022-02, Vol.8 (2), p.183 |
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| creator | Hare, Rasmus Krøger Arastehfar, Amir Rosendahl, Søren Charsizadeh, Arezoo Daneshnia, Farnaz Eshaghi, Hamid Mirhendi, Hossein Boekhout, Teun Hagen, Ferry Arendrup, Maiken Cavling |
| description | is the second most common cause of candidemia in some geographical areas and in children in particular. Yet, the proportion among children varies, for example, from 10.4% in Denmark to 24.7% in Tehran, Iran. As this species is also known to cause hospital outbreaks, we explored if the relatively high number of
pediatric cases in Tehran could in part be explained by undiscovered clonal outbreaks. Among 56
complex isolates, 50
were genotyped by Amplified Fragment Length Polymorphism (AFLP) fingerprinting and microsatellite typing and analyzed for nucleotide polymorphisms by
and
sequencing. AFLP fingerprinting grouped Iranian isolates in two main clusters. Microsatellite typing separated the isolates into five clonal lineages, of which four were shared with Danish isolates, and with no correlation to the AFLP patterns.
and
sequencing revealed few polymorphisms in
leading to amino-acid substitutions (D133Y, Q250K, I302T, and R398I), with no influence on azole-susceptibilities. Collectively, this study demonstrated that there were no clonal outbreaks at the Iranian pediatric ward. Although possible transmission of a diverse
community within the hospital cannot be ruled out, the study also emphasizes the necessity of applying appropriately discriminatory methods for outbreak investigation. |
| doi_str_mv | 10.3390/jof8020183 |
| format | article |
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pediatric cases in Tehran could in part be explained by undiscovered clonal outbreaks. Among 56
complex isolates, 50
were genotyped by Amplified Fragment Length Polymorphism (AFLP) fingerprinting and microsatellite typing and analyzed for nucleotide polymorphisms by
and
sequencing. AFLP fingerprinting grouped Iranian isolates in two main clusters. Microsatellite typing separated the isolates into five clonal lineages, of which four were shared with Danish isolates, and with no correlation to the AFLP patterns.
and
sequencing revealed few polymorphisms in
leading to amino-acid substitutions (D133Y, Q250K, I302T, and R398I), with no influence on azole-susceptibilities. Collectively, this study demonstrated that there were no clonal outbreaks at the Iranian pediatric ward. Although possible transmission of a diverse
community within the hospital cannot be ruled out, the study also emphasizes the necessity of applying appropriately discriminatory methods for outbreak investigation.</description><identifier>ISSN: 2309-608X</identifier><identifier>EISSN: 2309-608X</identifier><identifier>DOI: 10.3390/jof8020183</identifier><identifier>PMID: 35205937</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>AFLP ; Amplified fragment length polymorphism ; Candida parapsilosis ; Candida parapsilosis species complex ; Candidemia ; Children ; Discriminant analysis ; DNA fingerprinting ; Epidemics ; Ethics ; genotyping ; microsatellites ; Outbreaks ; Patients ; Pediatrics ; Population</subject><ispartof>Journal of fungi (Basel), 2022-02, Vol.8 (2), p.183</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-6c98f934c9bca42b2af95d20a004a67ff052af68788929de6609d10cb869a65c3</citedby><cites>FETCH-LOGICAL-c472t-6c98f934c9bca42b2af95d20a004a67ff052af68788929de6609d10cb869a65c3</cites><orcidid>0000-0002-4651-5224 ; 0000-0002-9796-023X ; 0000-0001-5202-6585 ; 0000-0002-4747-0144</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2633038792/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2633038792?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35205937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hare, Rasmus Krøger</creatorcontrib><creatorcontrib>Arastehfar, Amir</creatorcontrib><creatorcontrib>Rosendahl, Søren</creatorcontrib><creatorcontrib>Charsizadeh, Arezoo</creatorcontrib><creatorcontrib>Daneshnia, Farnaz</creatorcontrib><creatorcontrib>Eshaghi, Hamid</creatorcontrib><creatorcontrib>Mirhendi, Hossein</creatorcontrib><creatorcontrib>Boekhout, Teun</creatorcontrib><creatorcontrib>Hagen, Ferry</creatorcontrib><creatorcontrib>Arendrup, Maiken Cavling</creatorcontrib><title>Candidemia among Hospitalized Pediatric Patients Caused by Several Clonal Lineages of Candida parapsilosis</title><title>Journal of fungi (Basel)</title><addtitle>J Fungi (Basel)</addtitle><description>is the second most common cause of candidemia in some geographical areas and in children in particular. Yet, the proportion among children varies, for example, from 10.4% in Denmark to 24.7% in Tehran, Iran. As this species is also known to cause hospital outbreaks, we explored if the relatively high number of
pediatric cases in Tehran could in part be explained by undiscovered clonal outbreaks. Among 56
complex isolates, 50
were genotyped by Amplified Fragment Length Polymorphism (AFLP) fingerprinting and microsatellite typing and analyzed for nucleotide polymorphisms by
and
sequencing. AFLP fingerprinting grouped Iranian isolates in two main clusters. Microsatellite typing separated the isolates into five clonal lineages, of which four were shared with Danish isolates, and with no correlation to the AFLP patterns.
and
sequencing revealed few polymorphisms in
leading to amino-acid substitutions (D133Y, Q250K, I302T, and R398I), with no influence on azole-susceptibilities. Collectively, this study demonstrated that there were no clonal outbreaks at the Iranian pediatric ward. Although possible transmission of a diverse
community within the hospital cannot be ruled out, the study also emphasizes the necessity of applying appropriately discriminatory methods for outbreak investigation.</description><subject>AFLP</subject><subject>Amplified fragment length polymorphism</subject><subject>Candida parapsilosis</subject><subject>Candida parapsilosis species complex</subject><subject>Candidemia</subject><subject>Children</subject><subject>Discriminant analysis</subject><subject>DNA fingerprinting</subject><subject>Epidemics</subject><subject>Ethics</subject><subject>genotyping</subject><subject>microsatellites</subject><subject>Outbreaks</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Population</subject><issn>2309-608X</issn><issn>2309-608X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkl1r1jAUgIMobszd-AMk4I0I7zxN0jS5EaSoG7zgQAXvwmmavqa0TU3awfz1Znbuw6sTch4ezhchLws441zDuz50ChgUij8hx4yD3klQP54-eB-R05R6AChKJbXmz8kRLxmUmlfHpK9xan3rRo8UxzAd6HlIs19w8L9dSy9d63GJ3tJLXLyblkRrXFPONNf0q7tyEQdaD2HKYe8nhweXaOjoZkU6Y8Q5-SEkn16QZx0OyZ3exhPy_dPHb_X5bv_l80X9Yb-zomLLTlqtOs2F1Y1FwRqGnS5bBgggUFZdB2X-kqpSSjPdOilBtwXYJjeHsrT8hFxs3jZgb-boR4zXJqA3fz9CPBiMi7eDM6IRknHHC4cgCsFQCNc0DDqGulEosuv95prXZnStzRPIHT-SPs5M_qc5hCujVN6KYlnw5lYQw6_VpcWMPlk3DDi5sCbDJOdKCV1WGX39H9qHNebJbhRwVekb4duNsjGkFF13V0wB5uYizP1FZPjVw_Lv0H_7538AQYyxvA</recordid><startdate>20220212</startdate><enddate>20220212</enddate><creator>Hare, Rasmus Krøger</creator><creator>Arastehfar, Amir</creator><creator>Rosendahl, Søren</creator><creator>Charsizadeh, Arezoo</creator><creator>Daneshnia, Farnaz</creator><creator>Eshaghi, Hamid</creator><creator>Mirhendi, Hossein</creator><creator>Boekhout, Teun</creator><creator>Hagen, Ferry</creator><creator>Arendrup, Maiken Cavling</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4651-5224</orcidid><orcidid>https://orcid.org/0000-0002-9796-023X</orcidid><orcidid>https://orcid.org/0000-0001-5202-6585</orcidid><orcidid>https://orcid.org/0000-0002-4747-0144</orcidid></search><sort><creationdate>20220212</creationdate><title>Candidemia among Hospitalized Pediatric Patients Caused by Several Clonal Lineages of Candida parapsilosis</title><author>Hare, Rasmus Krøger ; 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Yet, the proportion among children varies, for example, from 10.4% in Denmark to 24.7% in Tehran, Iran. As this species is also known to cause hospital outbreaks, we explored if the relatively high number of
pediatric cases in Tehran could in part be explained by undiscovered clonal outbreaks. Among 56
complex isolates, 50
were genotyped by Amplified Fragment Length Polymorphism (AFLP) fingerprinting and microsatellite typing and analyzed for nucleotide polymorphisms by
and
sequencing. AFLP fingerprinting grouped Iranian isolates in two main clusters. Microsatellite typing separated the isolates into five clonal lineages, of which four were shared with Danish isolates, and with no correlation to the AFLP patterns.
and
sequencing revealed few polymorphisms in
leading to amino-acid substitutions (D133Y, Q250K, I302T, and R398I), with no influence on azole-susceptibilities. Collectively, this study demonstrated that there were no clonal outbreaks at the Iranian pediatric ward. Although possible transmission of a diverse
community within the hospital cannot be ruled out, the study also emphasizes the necessity of applying appropriately discriminatory methods for outbreak investigation.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35205937</pmid><doi>10.3390/jof8020183</doi><orcidid>https://orcid.org/0000-0002-4651-5224</orcidid><orcidid>https://orcid.org/0000-0002-9796-023X</orcidid><orcidid>https://orcid.org/0000-0001-5202-6585</orcidid><orcidid>https://orcid.org/0000-0002-4747-0144</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | AFLP Amplified fragment length polymorphism Candida parapsilosis Candida parapsilosis species complex Candidemia Children Discriminant analysis DNA fingerprinting Epidemics Ethics genotyping microsatellites Outbreaks Patients Pediatrics Population |
| title | Candidemia among Hospitalized Pediatric Patients Caused by Several Clonal Lineages of Candida parapsilosis |
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