Effectiveness of transverse tibial bone transport in treatment of diabetic foot ulcer: A systematic review and meta-analysis

Diabetic foot ulcerations (DFUs) are a common but highly morbid complication of long-standing diabetes, carrying high rates of associated major amputation and mortality. Transverse tibial bone transport (TTT) has recently been applied for treatment of DFUs with the aim of accelerating wound healing....

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2023-01, Vol.13, p.1095361-1095361
Main Authors: Hu, Xing-Xi, Xiu, Zheng-Zhong, Li, Gui-Chun, Zhang, Ji-Yuan, Shu, Long-Jun, Chen, Zhong, Li, Han, Zou, Qing-Feng, Zhou, Quan
Format: Article
Language:English
Subjects:
Amputation, Surgical
Diabetes Mellitus
Diabetic Foot - surgery
diabetic foot ulceration
Endocrinology
Fractures, Bone
Humans
meta-analysis
neovascularization
Tibia - surgery
transverse tibial bone transport
ulceration healing
Wound Healing
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Summary:Diabetic foot ulcerations (DFUs) are a common but highly morbid complication of long-standing diabetes, carrying high rates of associated major amputation and mortality. Transverse tibial bone transport (TTT) has recently been applied for treatment of DFUs with the aim of accelerating wound healing. This study was performed to evaluate the effectiveness and safety of TTT in patients with DFUs. Two authors independently retrieved the platforms of PubMed, Embase and CENTRAL, to identify studies associated with treatment of DFUs with TTT. Quantitative meta-analyses were performed to pool all available outcomes about the effectiveness and complications of TTT operation, with fixed- (I 50%) model according to I . A total of 7 studies, involving 818 participants, were included, with 661 participants treated with TTT operation. The pooled healing rate and limb salvage rate were 0.96 (95%CI: 0.93~0.98) and 0.98 (95%CI: 0.95~1.00) respectively after treatment with TTT. The pooled mean healing time was 15.03 (95%CI: 9.05~21.00) months. When compared with the pre-operative baseline values, the ankle-brachial index (ABI, MD: 0.23; 95%CI: 0.03~0.44; p
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.1095361