SARS-CoV-2 Induces Cytokine Responses in Human Basophils

Basophils play a key role in the orientation of immune responses. Though the interaction of SARS-CoV-2 with various immune cells has been relatively well studied, the response of basophils to this pandemic virus is not characterized yet. In this study, we report that SARS-CoV-2 induces cytokine resp...

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Bibliographic Details
Published in:Frontiers in immunology 2022-02, Vol.13, p.838448-838448
Main Authors: Bonam, Srinivasa Reddy, Chauvin, Camille, Levillayer, Laurine, Mathew, Mano Joseph, Sakuntabhai, Anavaj, Bayry, Jagadeesh
Format: Article
Language:English
Subjects:
Allergology
B7-H1 Antigen - metabolism
basophils
Basophils - immunology
Biomarkers - metabolism
Caco-2 cells
Cells, Cultured
COVID-19
COVID-19 - immunology
Humans
IL-13
IL-3
Immunology
Innate immunity
Interleukin-13 - metabolism
Interleukin-3 - metabolism
Life Sciences
SARS-CoV-2
SARS-CoV-2 - physiology
Virus Replication
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Summary:Basophils play a key role in the orientation of immune responses. Though the interaction of SARS-CoV-2 with various immune cells has been relatively well studied, the response of basophils to this pandemic virus is not characterized yet. In this study, we report that SARS-CoV-2 induces cytokine responses and in particular IL-13, in both resting and IL-3 primed basophils. The response was prominent under IL-3 primed condition. However, either SARS-CoV-2 or SARS-CoV-2-infected epithelial cells did not alter the expression of surface markers associated with the activation of basophils, such as CD69, CD13 and/or degranulation marker CD107a. We also validate that human basophils are not permissive to SARS-CoV-2 replication. Though increased expression of immune checkpoint molecule PD-L1 has been reported on the basophils from COVID-19 patients, we observed that SARS-CoV-2 does not induce PD-L1 on the basophils. Our data suggest that basophil cytokine responses to SARS-CoV-2 might help in reducing the inflammation and also to promote antibody responses to the virus.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.838448