The behavioral and neural effects of parietal theta burst stimulation on the grasp network are stronger during a grasping task than at rest

• Published in: Frontiers in neuroscience 2023-10, Vol.17, p.1198222-1198222
• Main Authors: Goldenkoff, Elana R, Deluisi, Joseph A, Destiny, Danielle P, Lee, Taraz G, Michon, Katherine J, Brissenden, James A, Taylor, Stephan F, Polk, Thad A, Vesia, Michael
• Format: Article
• Language: English
• Subjects: Behavior; Brain research; Cortex (motor); Cortex (parietal); Electrodes; Excitability; Experiments; functional connectivity; Grasping; Magnetic fields; manual dexterity; Motor task performance; Neuromodulation; Neuroplasticity; Neuroscience; Pilot projects; Planning; plasticity; state-dependency; theta burst stimulation; Transcranial magnetic stimulation
• ISSN: 1662-4548; 1662-453X; 1662-453X
• DOI: 10.3389/fnins.2023.1198222

Repetitive transcranial magnetic stimulation (TMS) is widely used in neuroscience and clinical settings to modulate human cortical activity. The effects of TMS on neural activity depend on the excitability of specific neural populations at the time of stimulation. Accordingly, the brain state at the time of stimulation may influence the persistent effects of repetitive TMS on distal brain activity and associated behaviors. We applied intermittent theta burst stimulation (iTBS) to a region in the posterior parietal cortex (PPC) associated with grasp control to evaluate the interaction between stimulation and brain state. Across two experiments, we demonstrate the immediate responses of motor cortex activity and motor performance to state-dependent parietal stimulation. We randomly assigned 72 healthy adult participants to one of three TMS intervention groups, followed by electrophysiological measures with TMS and behavioral measures. Participants in the first group received iTBS to PPC while performing a grasping task concurrently. Participants in the second group received iTBS to PPC while in a task-free, resting state. A third group of participants received iTBS to a parietal region outside the cortical grasping network while performing a grasping task concurrently. We compared changes in motor cortical excitability and motor performance in the three stimulation groups within an hour of each intervention. We found that parietal stimulation during a behavioral manipulation that activates the cortical grasping network increased downstream motor cortical excitability and improved motor performance relative to stimulation during rest. We conclude that constraining the brain state with a behavioral task during brain stimulation has the potential to optimize plasticity induction in cortical circuit mechanisms that mediate movement processes.