Continuous Flow Esterification of a H -Phosphinic Acid, and Transesterification of H -phosphinates and H -Phosphonates under Microwave Conditions

The microwave (MW)-assisted direct esterification of phenyl- -phosphinic acid, transesterification of the alkyl phenyl- -phosphinates so obtained, and the similar reaction of dibenzyl phosphite (DBP) were investigated in detail, and the batch accomplishments were translated into a continuous flow op...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-02, Vol.25 (3), p.719
Main Authors: Kiss, Nóra Zsuzsa, Henyecz, Réka, Keglevich, György
Format: Article
Language:English
Subjects:
Acids
Additives
Alcohol
Continuous flow
Conversion
Esterification
Flow velocity
h-phosphinates
h-phosphinic acid
h-phosphonates
microwave flow reactor
Optimization
Organic chemicals
Pharmaceutical industry
Phosphinic acid
Phosphonates
Reagents
Transesterification
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Summary:The microwave (MW)-assisted direct esterification of phenyl- -phosphinic acid, transesterification of the alkyl phenyl- -phosphinates so obtained, and the similar reaction of dibenzyl phosphite (DBP) were investigated in detail, and the batch accomplishments were translated into a continuous flow operation that, after optimization of the parameters, such as temperature and flow rate, proved to be more productive. Alcoholysis of DBP is a two-step process involving an intermediate phosphite with two different alkoxy groups. The latter species are of synthetic interest, as precursors for optically active reagents.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25030719