Unusual Phenotype and Disease Trajectory in Kearns–Sayre Syndrome

Objective. To describe unusual course and unusual phenotypic features in an adult patient with Kearns–Sayre syndrome (KSS). Case Report. The patient is a 49-year-old male with KSS, diagnosed clinically upon the core features, namely, onset before the age 20 of years, pigmentary retinopathy, and opht...

Full description

Saved in:
Bibliographic Details
Published in:Case reports in neurological medicine 2020-02, Vol.2020 (2020), p.1-6
Main Authors: Hummel, Thomas, Stöllberger, Claudia, Winklehner, Michael, Finsterer, Josef
Format: Article
Language:English
Subjects:
Age
Antibiotics
Ataxia
Austria
Biopsy
Case Report
Case reports
Cataracts
Congenital diseases
Coronary vessels
Cysts
Diabetes
Diseases
Encephalitis
Gait
Genetic aspects
Genotype & phenotype
Hypertension
Indapamide
Infections
Liver
Magnetic resonance imaging
Migraine
Mitochondrial DNA
Premature birth
Proteins
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective. To describe unusual course and unusual phenotypic features in an adult patient with Kearns–Sayre syndrome (KSS). Case Report. The patient is a 49-year-old male with KSS, diagnosed clinically upon the core features, namely, onset before the age 20 of years, pigmentary retinopathy, and ophthalmoparesis, and the complementary features, namely, elevated CSF protein, cardiac conduction defects, and cerebellar ataxia. The patient presented also with other previously described features, such as diabetes, short stature, white matter lesions, hypoacusis, migraine, hepatopathy, steatosis hepatis, hypocorticism (hyponatremia), and cataract. Unusual features the patient presented with were congenital anisocoria, severe caries, liver cysts, pituitary enlargement, desquamation of hands and feet, bone chondroma, aortic ectasia, dermoidal cyst, and sinusoidal polyposis. The course was untypical since most of the core phenotypic features developed not earlier than in adulthood. Conclusions. KSS is a multisystem disease, but the number of tissues affected is higher than so far anticipated. KSS should be considered even if core features develop not earlier than in adulthood and if unusual features accompany the presentation.
ISSN:2090-6668
2090-6676
DOI:10.1155/2020/7368527