Site-Specific Variation in Familial Cancer as Suggested by Family History, Multiple Primary Cancer, Age at Onset, and Sex Ratio Associated With Upper, Middle, and Lower Third Esophageal and Gastric Cardia Carcinoma

In China, esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) differ in terms of multiple primary cancer (MPC) and male-to-female sex ratio (MFSR). We studied site-specific variation in familial cancer by comparing family history (FH), MPC, age at onset (AO), and MFSR a...

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Bibliographic Details
Published in:Frontiers in oncology 2020-10, Vol.10, p.579379-579379
Main Authors: Wen, Denggui, Wen, Junpeng, Zou, Wendi, Yang, Yi, Wen, Xiaoduo, Chen, Yuetong, Akazawa, Kohei, Geng, Cuizhi, Shan, Baoen
Format: Article
Language:English
Subjects:
esophageal squamous cell carcinoma
familial cancer
family history of cancer
gastric cardia adenocarcinoma
median onset age
multiple primary cancer
Oncology
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Summary:In China, esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) differ in terms of multiple primary cancer (MPC) and male-to-female sex ratio (MFSR). We studied site-specific variation in familial cancer by comparing family history (FH), MPC, age at onset (AO), and MFSR among 8768 patients with ESCC/GCA. ESCC/GCA patients with a positive FH are associated with a significantly higher rate of MPC and a younger AO than those without (sex-specifically: MPC 1.6% vs. 0.7%,
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2020.579379