Studying the Effect of Sertraline in Reducing Aggressive Behavior in Patients with Major Depression

• Published in: Advanced pharmaceutical bulletin 2017-06, Vol.7 (2), p.275-279
• Main Authors: Farnam, Alireza, MehrAra, Arezoo, Dadashzadeh, Hossein, Chalabianlou, Golamreza, Safikhanlou, Salman
• Format: Article
• Language: English
• Subjects: Aggression; Aggressiveness; Antidepressants; Anxiety; Depression; Mental depression; Mental disorders; Sertraline; STAXI-II; Studies; Womens health
• ISSN: 2228-5881; 2251-7308
• DOI: 10.15171/apb.2017.033

According to the revised version of the fourth edition of the Diagnostic and Statistical book of DSM-IV-TR, mental disorders contain 17 main categories (children's disorders, mood etc) and 375 disorders (major depression and schizophrenia etc.).1 It can be said that mental disorders are the greatest public health problems of the current era, such that depression has exceeded forecasts and has become the biggest cause of the disease.2 Depression occurs in about one of five women and one in ten men in a lifetime.3 In addition to the problems caused by depression, there is an idea that aggression plays a major role in depression development which has been fused in psychiatric thinking composition.4 Emotion and aggressive behavior is a common element of a whole hypersensitivity in response to any threat and tend to attack.5 Emotion and aggressive behaviors include a spectrum such that their common elements are hypersensitivity in response to any threat and tend to attack. Anger attacks in 53 to 71% of outpatient depression treated with anti-depressants such as Fluoxetine, sertraline and imipramine disappeared. [...]the amount of anger attacks after treatment with Fluoxetine (7 to 6%) have no difference with the observed data after treatment with sertraline (8%) and imipramine (10%) and these values are less than the incidence associated with placebo (20%). [...]since the serotonergic neurotransmitter system is involved in the regulation of aggressive behavior in humans and animals, it can be assumed that anti-depressants affective on this system can be effective in depressed patients with dramatic aggression.10 In their previous study, Mezza et al. revealed the reduction of HR and HRV which confirms vagal activity in aggressive patients.11 In one study, it was found that there is a relationship between decrease in DBP, SBP and HR and increase in the aggressive behavior of preschool children.12 It was also found that SCL was higher in patients with a greater score of aggression, also anger triggers driving under the influence at the time of placement.12 In another study in 2013, Baker et al. concluded that reduction of skin conductance activity (SCA) in babies predict aggressive behavior at 3 years of age.13 Dibajnia and Moghadasin reported that numerous studies show the association between experience and expression of anger, depression, anxiety and stress.14 Researchers also reported that based on Pearson correlation coefficient and stepwise regression analysi