Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives

This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using t...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2010-03, Vol.15 (4), p.2114-2123
Main Authors: Zhou, Wei-Ming, He, Rong-Rong, Ye, Jian-Tao, Zhang, Na, Liu, De-Yu
Format: Article
Language:English
Subjects:
5-fluorouracil
ampelopsin
anticancer activity
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cancer
Cell Line, Tumor
Flavanones - chemical synthesis
Flavanones - chemistry
Flavanones - pharmacology
Flavonoids - chemical synthesis
Flavonoids - chemistry
Flavonoids - pharmacology
Fluorouracil - analogs & derivatives
Fluorouracil - chemical synthesis
Fluorouracil - chemistry
Fluorouracil - pharmacology
Humans
Hydrochloric acid
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules15042114