Markers of systemic inflammation in response to osmotic stimulus in healthy volunteers

Osmotic stimulus or stress results in vasopressin release. Animal and human in vitro studies have shown that inflammatory parameters, such as interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α), increase in parallel in the central nervous system and bronchial, corneal or intestinal epithelial c...

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Bibliographic Details
Published in:Endocrine Connections 2019-09, Vol.8 (9), p.1282-1287
Main Authors: Sailer, Clara Odilia, Wiedemann, Sophia Julia, Strauss, Konrad, Schnyder, Ingeborg, Fenske, Wiebke Kristin, Christ-Crain, Mirjam
Format: Article
Language:English
Subjects:
copeptin
hyperosmolality
interleukin-6
interleukin-8
TNF-α
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Summary:Osmotic stimulus or stress results in vasopressin release. Animal and human in vitro studies have shown that inflammatory parameters, such as interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α), increase in parallel in the central nervous system and bronchial, corneal or intestinal epithelial cell lines in response to osmotic stimulus. Whether osmotic stimulus directly causes a systemic inflammatory response in humans is unknown. We therefore investigated the influence of osmotic stimulus on circulatory markers of systemic inflammation in healthy volunteers. In this prospective cohort study, 44 healthy volunteers underwent a standardized test protocol with an osmotic stimulus leading into the hyperosmotic/hypernatremic range (serum sodium ≥150 mmol/L) by hypertonic saline infusion. Copeptin – a marker indicating vasopressin activity – serum sodium and osmolality, plasma IL-8 and TNF-α were measured at baseline and directly after osmotic stimulus. Median (range) serum sodium increased from 141 mmol/L (136, 147) to 151 mmol/L (145, 154) (P 
ISSN:2049-3614
2049-3614
DOI:10.1530/EC-19-0280