Expression and Clinical Significance of Novel Long Noncoding RNA Fibroblast Growth Factor 10AS and FGF10 in Colorectal Cancer

Colorectal cancer (CRC) imposes great health burdens worldwide. Growth factors contribute to cell growth, differentiation, angiogenesis and, most importantly, tumour formation in many types of cancers. Natural antisense transcripts (NATs) are inclusively predicted to play a major role in cancer prog...

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Bibliographic Details
Published in:Cell journal (Yakhteh) 2021-11, Vol.23 (6), p.665-673
Main Authors: Rejali, Leili, Seyedna, Seyed Yoosef, Asadzadeh Aghdaei, Hamid, Nazemalhosseini Mojarad, Ehsan, Hashemi, Mehrdad
Format: Article
Language:English
Subjects:
Angiogenesis
Antisense RNA
biomarker
Biomarkers
Cancer
Cell differentiation
Clinical significance
Colorectal cancer
Colorectal carcinoma
Confidence intervals
Differentiation
Fibroblast growth factor 10
Fibroblasts
Gene expression
Growth factors
Immunohistochemistry
long noncoding rna
Metastases
Original
Polymerase chain reaction
Regression analysis
Statistical analysis
Tissues
Tumors
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Summary:Colorectal cancer (CRC) imposes great health burdens worldwide. Growth factors contribute to cell growth, differentiation, angiogenesis and, most importantly, tumour formation in many types of cancers. Natural antisense transcripts (NATs) are inclusively predicted to play a major role in cancer progression. The present study aims to evaluate the relationship of fibroblast growth factor 10 ( ) and novel long noncoding RNA (lncRNA) antisense ( ) expression with clinicopathologic features in CRC progression to designate a biomarker for CRC early detection. This cross-sectional study was conducted on 100 CRC tumour and parallel adjacent normal tissues. We added 30 normal cases to enhance accuracy of the test. The expression levels of and were evaluated by real-time polymerase chain reaction (PCR). The findings were validated by measuring expression levels in the HT29 and SW480 cell lines. Immunohistochemistry analysis was performed systematically to evaluate FGF10 protein expression. The Mann-Whitney U test with Cox regression analysis were applied. P
ISSN:2228-5806
2228-5814
DOI:10.22074/cellj.2021.7487