The Microbiota-Gut-Brain Axis in Depression: The Potential Pathophysiological Mechanisms and Microbiota Combined Antidepression Effect

Depression is a kind of worldwide mental illness with the highest morbidity and disability rate, which is often accompanied by gastrointestinal symptoms. Experiments have demonstrated that the disorder of the intestinal microbial system structure plays a crucial role in depression. The gut-brain axi...

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Bibliographic Details
Published in:Nutrients 2022-05, Vol.14 (10), p.2081
Main Authors: Zhu, Fangyuan, Tu, Huaijun, Chen, Tingtao
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antidepressants
Autism
Brain
Brain-Gut Axis
Central nervous system
Chronic illnesses
depression
Depression - therapy
Digestive system
Dopamine
Gastrointestinal Microbiome - physiology
Gastrointestinal symptoms
gut microbiota
gut–brain axis
Intestinal microflora
Intestine
Irritable bowel syndrome
Mental depression
Mental disorders
Metabolism
Metabolites
Microbiomes
Microbiota
Microorganisms
Morbidity
Nervous system
Parkinson's disease
Physiology
Probiotics
Probiotics - therapeutic use
Review
Serotonin
Stress
Vitamin deficiency
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Summary:Depression is a kind of worldwide mental illness with the highest morbidity and disability rate, which is often accompanied by gastrointestinal symptoms. Experiments have demonstrated that the disorder of the intestinal microbial system structure plays a crucial role in depression. The gut-brain axis manifests a potential linkage between the digestion system and the central nervous system (CNS). Nowadays, it has become an emerging trend to treat diseases by targeting intestinal microorganisms (e.g., probiotics) and combining the gut-brain axis mechanism. Combined with the research, we found that the incidence of depression is closely linked to the gut microbiota. Moreover, the transformation of the gut microbiota system structure is considered to have both positive and negative regulatory effects on the development of depression. This article reviewed the mechanism of bidirectional interaction in the gut-brain axis and existing symptom-relieving measures and antidepression treatments related to the gut microbiome.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14102081