Histochemical and morphological aspects of fresh frozen bone: a preliminary study

Bone graft are used in dentistry for the reconstruction of severely atrophic jaws. Fresh frozen bone has no osteogenic property but it has osteoconductive and osteoinductive properties because its matrix contains growth factors such as vascular endothelial growth factor. The purpose of the present s...

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Bibliographic Details
Published in:European journal of histochemistry 2016-12, Vol.60 (4), p.2642-2642
Main Authors: De Ponte, F S, Cutroneo, G, Falzea, R, Rizzo, G, Catalfamo, L, Favaloro, A, Vermiglio, G, Runci, M, Centofanti, A, Anastasi, G
Format: Article
Language:English
Subjects:
Bone Transplantation
Brief Report
Cryopreservation
Female
fluorescence antibody technique
Fresh frozen bone
histological techniques
Humans
Male
Maxilla - cytology
Maxilla - metabolism
osteoblast
osteoclast
VEGF
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Summary:Bone graft are used in dentistry for the reconstruction of severely atrophic jaws. Fresh frozen bone has no osteogenic property but it has osteoconductive and osteoinductive properties because its matrix contains growth factors such as vascular endothelial growth factor. The purpose of the present study was to evaluate morphological and protein expression characteristics of fresh frozen bone before graft and after six months of graft in patients who needed maxillary reconstruction. After 6 month of graft we observed the presence of viable bone as evidenced by full osteocyte lacunae and by the presence of RANKR, osteocalcin positive cells and vascular endothelial growth factor. In conclusion, our findings show that the fresh frozen bone after six month of graft is for the most part viable bone, encouraging its use as an alternative to autogenous bone for reconstructing maxillary bone defects prior to implant.
ISSN:1121-760X
2038-8306
DOI:10.4081/ejh.2016.2642