Spices Mixture Containing Garlic, Ginger and Nutmeg Has Protective Effects on the Kidneys and Liver of Cadmium Exposed Rats

• Published in: Advanced pharmaceutical bulletin 2016-06, Vol.6 (2), p.271-274
• Main Authors: Ugwuja, Emmanuel Ike, Erejuwa, Omotayo O., Ugwu, Nicholas C.
• Format: Article
• Language: English
• Subjects: Cadmium toxicity; Hepatotoxicity; Oxidative stress; Short Communication; Spices mixture
• ISSN: 2228-5881; 2251-7308
• DOI: 10.15171/apb.2016.038

Purpose: To determine the potential protective effect of spice mixture containing garlic, ginger and nutmeg on the liver and kidney of cadmium exposed rats. Methods: Male albino rats (n=30) weighing 120 – 180 g, grouped into five (1-5) of 6 rats/group were studied. Group 1 (NC) rats were administered distilled water (1 ml) orally for 4 weeks and served as the negative control while group 2 (PC) rats were administered low dose (LD) cadmium (25 mg/kg body weight) orally for 4 weeks and served as positive control. Group 3 (TBE) rats were treated with spice mixture (SM); 300 mg/kg body weight orally for 2 weeks and then administered LD cadmium for 4 weeks. While group 4 (CET) rats were concurrently administered LD cadmium and SM for 4 weeks, group 5 (TAE) rats were administered LD cadmium for 4 weeks and then treated with SM for 2 weeks. The whole experiment lasted for 42 day after which the animals were sacrificed and blood collected for determination of biochemical parameters using standard procedures and techniques. Results: Exposure to Cd produced greater increases in the liver function parameters. However treatment with SM significantly (p