Catalyst-free ultrasound assisted novel one pot pseudo five component synthesis of aryl-bis-[1H-pyrazol-5-ol-4-yl]methanes, het(aryl)-bis-[1H-pyrazol-5-ol-4-yl]methanes and their 1-phenyl derivatives in aqueous medium

An efficient, catalyst-free and eco-friendly ultrasound-assisted novel one-pot pseudo-five-component synthesis of aryl-bis-[1H-pyrazol-5-ol-4yl]methanes, het(aryl)-bis-[1H-pyrazol-5-ol-4yl]methanes and their 1-phenyl derivatives in water is reported. The products were obtained in excellent yield in...

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Bibliographic Details
Published in:Green synthesis and catalysis 2022-05, Vol.3 (2), p.190-193
Main Authors: S, Sudha, Pasha, Mohamed Afzal
Format: Article
Language:English
Subjects:
Aromatic/het (aryl) aldehydes
Bis pyrozolyl-methanes
Ethyl acetoacetate
Hydrazine/phenyl hydrazine
One-pot multi-component synthesis
Ultrasound
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Summary:An efficient, catalyst-free and eco-friendly ultrasound-assisted novel one-pot pseudo-five-component synthesis of aryl-bis-[1H-pyrazol-5-ol-4yl]methanes, het(aryl)-bis-[1H-pyrazol-5-ol-4yl]methanes and their 1-phenyl derivatives in water is reported. The products were obtained in excellent yield in shorter duration with high purity, by simple filtration. This synthetic methodology has been optimized and discussed herein. An efficient, catalyst-free and eco-friendly ultrasound assisted novel catalyst-free one pot pseudo five-component synthesis of aryl-bis-[1H-pyrazol-5-ol-4yl]methanes, het(aryl)-bis-[1H-pyrazol-5-ol-4yl]methanes and their 1-phenyl derivatives in water is reported. The products were obtained in excellent yield in short durations with high purity. This energy efficient synthetic methodology has been optimized and discussed herein. [Display omitted]
ISSN:2666-5549
2666-5549
DOI:10.1016/j.gresc.2022.03.011