Diarrhoeagenic Escherichia coli associated with childhood diarrhoea in Osun state, Nigeria

Diarrhoea is a major public health concern in developing countries, usually exacerbated by poor water, sanitation and hygiene but its aetiology is under-studied, particularly away from capital cities. We identified diarrhoeagenic Escherichia coli (DEC) from stools collected in Ile-Ife and Ilesa, Osu...

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Bibliographic Details
Published in:BMC infectious diseases 2024-09, Vol.24 (1), p.928-8, Article 928
Main Authors: Olayinka, Ademola A, Oginni-Falajiki, Ibukunoluwa O, Okeke, Iruka N, Aboderin, Aaron O
Format: Article
Language:English
Subjects:
Ampicillin
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Breast feeding
Carbapenems
Care and treatment
Caregivers
Chi-square test
Child, Preschool
Childhood
Children
Chronology
Complications and side effects
Developing countries
Diagnosis
Diarrhea
Diarrhea - epidemiology
Diarrhea - microbiology
Diarrhoea
Diarrhoeagenic Escherichia coli
Drug resistance in microorganisms
Drug Resistance, Bacterial
E coli
Education
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli - isolation & purification
Escherichia coli infections
Escherichia coli Infections - epidemiology
Escherichia coli Infections - microbiology
Feces - microbiology
Female
Genes
Health aspects
Health care
Humans
Hygiene
Infant
Infant, Newborn
LDCs
Male
Microbial Sensitivity Tests
Nigeria - epidemiology
Pathogens
Prevention
Public health
Quinolones
Rainy season
Regional differences
Risk Factors
Salmonella
Sanitation
Shiga toxin
Sulfonamides
Toxins
Trimethoprim
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Summary:Diarrhoea is a major public health concern in developing countries, usually exacerbated by poor water, sanitation and hygiene but its aetiology is under-studied, particularly away from capital cities. We identified diarrhoeagenic Escherichia coli (DEC) from stools collected in Ile-Ife and Ilesa, Osun state, Nigeria and determined their antibiotic resistance profiles. Stool samples from 167 children with diarrhoea and 334 controls under the age of 5 years were cultured for Escherichia coli and Salmonella. Bacterial isolates were identified biochemically and DEC were identified by PCR. Antimicrobial susceptibility testing was by modified Kirby-Bauer disc diffusion method in accordance with the CLSI guidelines. Data were analyzed using Chi-square and Fisher's exact tests. Diarrhoea infection is significantly high among children under 12 months (p = 0.002), caregivers without at least primary school education (p = 0.006), breastfeeding for under 6 months (p˂0.001), and caregivers who were siblings (p = 0.004). DEC was detected in 69(41.3%) cases but only 86(25.7%) controls (p 
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-024-09793-0