Lower Plasma Melatonin in the Intervertebral Disk Degeneration Patients Was Associated with Increased Proinflammatory Cytokines

Intervertebral disc degeneration (IDD) was considered to be the pathological basis of intervertebral disc herniation (IDH). However, the plasma melatonin in the IDD cases and healthy controls remained unclear. In this case-control study, a total of 71 IDD cases and 54 healthy controls were enrolled...

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Bibliographic Details
Published in:Clinical interventions in aging 2021-01, Vol.16, p.215-224
Main Authors: Tian, Yixing, Ji, Yiming, Mei, Xin, Pan, Jun, He, Wenye, Sun, Jiajia, Wan, Kaichen, Yang, Huilin
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Back pain
biomarker
Biomarkers
Cardiovascular disease
Case-Control Studies
Cerebrovascular disease
Cytokines
Cytokines - biosynthesis
Degeneration (Pathology)
Development and progression
Female
Fractures
Health aspects
Hernia
Humans
Hypertension
Inflammation Mediators - metabolism
inflammatory factors
Interleukin-6 - biosynthesis
intervertebral disc degeneration
Intervertebral Disc Degeneration - blood
Intervertebral Disc Degeneration - physiopathology
Intervertebral disk
Intervertebral disk displacement
Male
Measurement
Melatonin
Melatonin - analysis
Melatonin - biosynthesis
Middle Aged
Original Research
Physiological aspects
Physiology
Plasma
Prospective Studies
Rheumatoid arthritis
ROC Curve
Severity of Illness Index
Spinal cord
Surgery
Tension tests
Trauma
Tumor Necrosis Factor-alpha - biosynthesis
Variance analysis
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Summary:Intervertebral disc degeneration (IDD) was considered to be the pathological basis of intervertebral disc herniation (IDH). However, the plasma melatonin in the IDD cases and healthy controls remained unclear. In this case-control study, a total of 71 IDD cases and 54 healthy controls were enrolled between April 2020 and August 2020. The diagnostic effect of plasma melatonin for IDD was detected using receiver operating characteristic curve. The correlations between two continuous variables were detected with the Pearson linear analyses. It was found that lower melatonin concentration was detected in the IDD cases (1.906 ± 1.041 vs 3.072 ± 0.511 pg/mL,
ISSN:1178-1998
1176-9092
1178-1998
DOI:10.2147/CIA.S290045