Correlations between subfoveal choroidal thickness, macular thickness, and visual outcome in neovascular age-related macular degeneration using swept source OCT: insights from intravitreal aflibercept treatment

BACKGROUNDAge-related macular degeneration (AMD) is a leading cause of visual impairment among individuals aged 50 and above, often resulting in irreversible vision loss (1). Currently, antiangiogenic therapy is the primary treatment approach for neovascular AMD (2). The choroid has gained significa...

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Published in:International journal of retina and vitreous 2023-11, Vol.9 (1), p.70-70, Article 70
Main Authors: Beraldo, Daniel P., Rezende, Marcussi P., Alexander, João G., Polido, Júlia, Belfort, Rubens, Cabral, Thiago
Format: Article
Language:English
Subjects:
Aflibercept
Age-related macular degeneration
Choroidal thickness
Macular thickness
Neovascular
OCT Swept Source
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Summary:BACKGROUNDAge-related macular degeneration (AMD) is a leading cause of visual impairment among individuals aged 50 and above, often resulting in irreversible vision loss (1). Currently, antiangiogenic therapy is the primary treatment approach for neovascular AMD (2). The choroid has gained significant attention in recent years due to its involvement in various ocular pathologies (7). The objective of this study was to evaluate visual acuity and correlate pre-treatment variables, such as foveal thickness and choroidal thickness, with post-treatment outcomes.MATERIALS AND METHODSThis study was designed as a prospective interventional study to investigate the changes in choroidal and macular thickness in patients with neovascular AMD who received intravitreal aflibercept injections. The study utilized medical records and employed Swept Source Optical Coherence Tomography (OCT-SS) for evaluation. The data was collected from patients treated in Presidente Prudente, Brazil, during a three-month load dose period.RESULTSThe best-corrected mean visual acuity significantly improved from 1.0 logarithm of the minimum resolution angle (logMAR) units to 0.55 logMAR after treatment with aflibercept (p 
ISSN:2056-9920
2056-9920
DOI:10.1186/s40942-023-00506-4