Plasma AGE and Oxidation Products, Renal Function, and Preeclampsia in Pregnant Women with Type 1 Diabetes: A Prospective Observational Study

Aims. We aimed to determine whether plasma advanced glycation end products or oxidation products (AGE/oxidation-P) predict altered renal function and/or preeclampsia (PE) in pregnant women with type 1 diabetes. Methods. Prospectively, using a nested case-control design, we studied 47 pregnant women...

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Published in:Journal of diabetes research 2023, Vol.2023, p.1-10
Main Authors: Kelly, Clare B., Karanchi, Harsha, Yu, Jeremy Y., Leyva, Misti J., Jenkins, Alicia J., Nankervis, Alison J., Hanssen, Kristian F., Garg, Satish K., Scardo, James A., Hammad, Samar M., Aston, Christopher E., Beisswenger, Paul J., Lyons, Timothy J.
Format: Article
Language:English
Subjects:
Age
Angiogenesis
Cholesterol
Chromatography
Creatinine
Diabetes
High density lipoprotein
Hypertension
Kinases
Low density lipoprotein
Mass spectrometry
Observational studies
Oxidation
Oxidative stress
Plasma
Preeclampsia
Pregnancy
Scientific imaging
Women
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Summary:Aims. We aimed to determine whether plasma advanced glycation end products or oxidation products (AGE/oxidation-P) predict altered renal function and/or preeclampsia (PE) in pregnant women with type 1 diabetes. Methods. Prospectively, using a nested case-control design, we studied 47 pregnant women with type 1 diabetes, of whom 23 developed PE and 24 did not. Nineteen nondiabetic, normotensive pregnant women provided reference values. In plasma obtained at ~12, 22, and 32 weeks’ gestation (visits 1, 2, and 3; V1-V3), we measured five AGE products (carboxymethyllysine (CML), carboxyethyl-lysine (CEL), methylglyoxal-hydroimidazolone (MGH1), 3-deoxyglucosone hydroimidazolone (3DGH), and glyoxal-hydroimidazolone (GH1)) and four oxidation products (methionine sulfoxide (MetSO), 2-aminoadipic acid (2-AAA), 3-nitrotyrosine (3NT), and dityrosine (DT)), by liquid chromatography/mass spectroscopy. Clinical outcomes were “estimated glomerular filtration rate” (eGFR) at each visit and onset of PE. Results. In diabetic women, associations between AGE/oxidation-P and eGFR were found only in those who developed PE. In this group, CEL, MGH1, and GH1 at V2 and CML, CEL, MGH1, and GH1 at V3 were inversely associated with contemporaneous eGFR, while CEL, MGH1, 3DGH, and GH1 at V2 were inversely associated with eGFR at V3 (all p
ISSN:2314-6745
2314-6753
DOI:10.1155/2023/8537693