Research Progress on the Mechanism of Itaconate Regulating Macrophage Immunometabolism

The field of immunology is undergoing rapid and dramatic changes. Immunometabolism, a change in metabolic pathways within immune cells, is a key determinant in the activation of immune cells, and intermediates of immunometabolic processes which can influence inflammatory gene expression and play a r...

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Bibliographic Details
Published in:Frontiers in immunology 2022-06, Vol.13, p.937247-937247
Main Authors: Shi, Jia, Cai, Cheng
Format: Article
Language:English
Subjects:
Immunology
immunometabolism
itaconate
macrophages
research progress
tricarboxylic acid cycle
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Summary:The field of immunology is undergoing rapid and dramatic changes. Immunometabolism, a change in metabolic pathways within immune cells, is a key determinant in the activation of immune cells, and intermediates of immunometabolic processes which can influence inflammatory gene expression and play a role in inflammation. Itaconate is one of the most representative metabolites, produced in the tricarboxylic acid cycle (TCA cycle), which links macrophage metabolism, oxidative stress response and immune response to regulate macrophage activity, playing an important role in the function of macrophages. In this paper, we review the mechanisms of the metabolite itaconate and its derivatives in the regulation of macrophage immune metabolism, intending to gain further insight into the role and mechanisms of this metabolite in macrophages and provide new ideas for the mechanisms and treatment of clinical diseases.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.937247