Research Progress on the Mechanism of Itaconate Regulating Macrophage Immunometabolism

The field of immunology is undergoing rapid and dramatic changes. Immunometabolism, a change in metabolic pathways within immune cells, is a key determinant in the activation of immune cells, and intermediates of immunometabolic processes which can influence inflammatory gene expression and play a r...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2022-06, Vol.13, p.937247-937247
Main Authors: Shi, Jia, Cai, Cheng
Format: Article
Language:English
Subjects:
Immunology
immunometabolism
itaconate
macrophages
research progress
tricarboxylic acid cycle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c442t-ece1ccdd099fa013ed146d104b39535c8b86f52ed3eb4ad3db9a849a3d3e2b4d3
cites cdi_FETCH-LOGICAL-c442t-ece1ccdd099fa013ed146d104b39535c8b86f52ed3eb4ad3db9a849a3d3e2b4d3
container_end_page 937247
container_issue
container_start_page 937247
container_title Frontiers in immunology
container_volume 13
creator Shi, Jia
Cai, Cheng
description The field of immunology is undergoing rapid and dramatic changes. Immunometabolism, a change in metabolic pathways within immune cells, is a key determinant in the activation of immune cells, and intermediates of immunometabolic processes which can influence inflammatory gene expression and play a role in inflammation. Itaconate is one of the most representative metabolites, produced in the tricarboxylic acid cycle (TCA cycle), which links macrophage metabolism, oxidative stress response and immune response to regulate macrophage activity, playing an important role in the function of macrophages. In this paper, we review the mechanisms of the metabolite itaconate and its derivatives in the regulation of macrophage immune metabolism, intending to gain further insight into the role and mechanisms of this metabolite in macrophages and provide new ideas for the mechanisms and treatment of clinical diseases.
doi_str_mv 10.3389/fimmu.2022.937247
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_4bd69a442e5b429e87fa1d3d82a4d447</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_4bd69a442e5b429e87fa1d3d82a4d447</doaj_id><sourcerecordid>2688085986</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-ece1ccdd099fa013ed146d104b39535c8b86f52ed3eb4ad3db9a849a3d3e2b4d3</originalsourceid><addsrcrecordid>eNpVkctqHDEQRYVJsI3jD_BOy2xm3Hp0t7QJBJPHgE2CSbwVJan6YbpbE0ltyN9H4zHBro2K0tW5hS4hV6zaCqH0dTfO87rlFedbLVou2xNyzppGbgTn8t2r_oxcpvRYlZJaCFGfkjNRK8ZFK87Jwz0mhOgG-jOGPmJKNCw0D0jv0A2wjGmmoaO7DC4skJHeY79OkMelp3fgYtgP0CPdlV2WMGMGG6by5gN538GU8PLlvCC_v375dfN9c_vj2-7m8-3GScnzBh0y57yvtO6gYgI9k41nlbRC16J2yqqmqzl6gVaCF95qUFKDKANupRcXZHfk-gCPZh_HGeJfE2A0z4MQewMxj25CI61vNBRbrK3kGlXbAStIxUF6KdvC-nRk7Vc7o3e45AjTG-jbm2UcTB-ejOa1Vo0qgI8vgBj-rJiymcfkcJpgwbAmwxulKnXQFik7SssPphSx-2_DKnOI1zzHaw7xmmO84h93nJpw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2688085986</pqid></control><display><type>article</type><title>Research Progress on the Mechanism of Itaconate Regulating Macrophage Immunometabolism</title><source>PubMed Central Free</source><creator>Shi, Jia ; Cai, Cheng</creator><creatorcontrib>Shi, Jia ; Cai, Cheng</creatorcontrib><description>The field of immunology is undergoing rapid and dramatic changes. Immunometabolism, a change in metabolic pathways within immune cells, is a key determinant in the activation of immune cells, and intermediates of immunometabolic processes which can influence inflammatory gene expression and play a role in inflammation. Itaconate is one of the most representative metabolites, produced in the tricarboxylic acid cycle (TCA cycle), which links macrophage metabolism, oxidative stress response and immune response to regulate macrophage activity, playing an important role in the function of macrophages. In this paper, we review the mechanisms of the metabolite itaconate and its derivatives in the regulation of macrophage immune metabolism, intending to gain further insight into the role and mechanisms of this metabolite in macrophages and provide new ideas for the mechanisms and treatment of clinical diseases.</description><identifier>ISSN: 1664-3224</identifier><identifier>EISSN: 1664-3224</identifier><identifier>DOI: 10.3389/fimmu.2022.937247</identifier><identifier>PMID: 35812373</identifier><language>eng</language><publisher>Frontiers Media S.A</publisher><subject>Immunology ; immunometabolism ; itaconate ; macrophages ; research progress ; tricarboxylic acid cycle</subject><ispartof>Frontiers in immunology, 2022-06, Vol.13, p.937247-937247</ispartof><rights>Copyright © 2022 Shi and Cai 2022 Shi and Cai</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-ece1ccdd099fa013ed146d104b39535c8b86f52ed3eb4ad3db9a849a3d3e2b4d3</citedby><cites>FETCH-LOGICAL-c442t-ece1ccdd099fa013ed146d104b39535c8b86f52ed3eb4ad3db9a849a3d3e2b4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259868/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259868/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Shi, Jia</creatorcontrib><creatorcontrib>Cai, Cheng</creatorcontrib><title>Research Progress on the Mechanism of Itaconate Regulating Macrophage Immunometabolism</title><title>Frontiers in immunology</title><description>The field of immunology is undergoing rapid and dramatic changes. Immunometabolism, a change in metabolic pathways within immune cells, is a key determinant in the activation of immune cells, and intermediates of immunometabolic processes which can influence inflammatory gene expression and play a role in inflammation. Itaconate is one of the most representative metabolites, produced in the tricarboxylic acid cycle (TCA cycle), which links macrophage metabolism, oxidative stress response and immune response to regulate macrophage activity, playing an important role in the function of macrophages. In this paper, we review the mechanisms of the metabolite itaconate and its derivatives in the regulation of macrophage immune metabolism, intending to gain further insight into the role and mechanisms of this metabolite in macrophages and provide new ideas for the mechanisms and treatment of clinical diseases.</description><subject>Immunology</subject><subject>immunometabolism</subject><subject>itaconate</subject><subject>macrophages</subject><subject>research progress</subject><subject>tricarboxylic acid cycle</subject><issn>1664-3224</issn><issn>1664-3224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkctqHDEQRYVJsI3jD_BOy2xm3Hp0t7QJBJPHgE2CSbwVJan6YbpbE0ltyN9H4zHBro2K0tW5hS4hV6zaCqH0dTfO87rlFedbLVou2xNyzppGbgTn8t2r_oxcpvRYlZJaCFGfkjNRK8ZFK87Jwz0mhOgG-jOGPmJKNCw0D0jv0A2wjGmmoaO7DC4skJHeY79OkMelp3fgYtgP0CPdlV2WMGMGG6by5gN538GU8PLlvCC_v375dfN9c_vj2-7m8-3GScnzBh0y57yvtO6gYgI9k41nlbRC16J2yqqmqzl6gVaCF95qUFKDKANupRcXZHfk-gCPZh_HGeJfE2A0z4MQewMxj25CI61vNBRbrK3kGlXbAStIxUF6KdvC-nRk7Vc7o3e45AjTG-jbm2UcTB-ejOa1Vo0qgI8vgBj-rJiymcfkcJpgwbAmwxulKnXQFik7SssPphSx-2_DKnOI1zzHaw7xmmO84h93nJpw</recordid><startdate>20220623</startdate><enddate>20220623</enddate><creator>Shi, Jia</creator><creator>Cai, Cheng</creator><general>Frontiers Media S.A</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20220623</creationdate><title>Research Progress on the Mechanism of Itaconate Regulating Macrophage Immunometabolism</title><author>Shi, Jia ; Cai, Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-ece1ccdd099fa013ed146d104b39535c8b86f52ed3eb4ad3db9a849a3d3e2b4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Immunology</topic><topic>immunometabolism</topic><topic>itaconate</topic><topic>macrophages</topic><topic>research progress</topic><topic>tricarboxylic acid cycle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Jia</creatorcontrib><creatorcontrib>Cai, Cheng</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Jia</au><au>Cai, Cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Research Progress on the Mechanism of Itaconate Regulating Macrophage Immunometabolism</atitle><jtitle>Frontiers in immunology</jtitle><date>2022-06-23</date><risdate>2022</risdate><volume>13</volume><spage>937247</spage><epage>937247</epage><pages>937247-937247</pages><issn>1664-3224</issn><eissn>1664-3224</eissn><abstract>The field of immunology is undergoing rapid and dramatic changes. Immunometabolism, a change in metabolic pathways within immune cells, is a key determinant in the activation of immune cells, and intermediates of immunometabolic processes which can influence inflammatory gene expression and play a role in inflammation. Itaconate is one of the most representative metabolites, produced in the tricarboxylic acid cycle (TCA cycle), which links macrophage metabolism, oxidative stress response and immune response to regulate macrophage activity, playing an important role in the function of macrophages. In this paper, we review the mechanisms of the metabolite itaconate and its derivatives in the regulation of macrophage immune metabolism, intending to gain further insight into the role and mechanisms of this metabolite in macrophages and provide new ideas for the mechanisms and treatment of clinical diseases.</abstract><pub>Frontiers Media S.A</pub><pmid>35812373</pmid><doi>10.3389/fimmu.2022.937247</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1664-3224
ispartof Frontiers in immunology, 2022-06, Vol.13, p.937247-937247
issn 1664-3224
1664-3224
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_4bd69a442e5b429e87fa1d3d82a4d447
source PubMed Central Free
subjects Immunology
immunometabolism
itaconate
macrophages
research progress
tricarboxylic acid cycle
title Research Progress on the Mechanism of Itaconate Regulating Macrophage Immunometabolism
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T14%3A59%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Research%20Progress%20on%20the%20Mechanism%20of%20Itaconate%20Regulating%20Macrophage%20Immunometabolism&rft.jtitle=Frontiers%20in%20immunology&rft.au=Shi,%20Jia&rft.date=2022-06-23&rft.volume=13&rft.spage=937247&rft.epage=937247&rft.pages=937247-937247&rft.issn=1664-3224&rft.eissn=1664-3224&rft_id=info:doi/10.3389/fimmu.2022.937247&rft_dat=%3Cproquest_doaj_%3E2688085986%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c442t-ece1ccdd099fa013ed146d104b39535c8b86f52ed3eb4ad3db9a849a3d3e2b4d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2688085986&rft_id=info:pmid/35812373&rfr_iscdi=true