In Vitro Antischistosomal Activity of Bridelia ferruginea, Clausena anisata, Khaya senegalensis, and Vernonia amygdalina

Background. Schistosomiasis is caused by parasitic flatworms and the disease is endemic to most countries in sub-Saharan Africa including Ghana. The current therapeutic agent for managing this disease solely relies on praziquantel. The continual dependence on this single available drug could lead to...

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Bibliographic Details
Published in:Journal of tropical medicine 2024-03, Vol.2024, p.8074291-9
Main Authors: Kuevi, Deryl Nii Okantey, Keiser, Jennifer, Häberli, Cécile, Owusu-Senyah, Abena Konadu, Ahiabu, Mawutor Kwame
Format: Article
Language:English
Subjects:
Drug resistance
Health aspects
Medicinal plants
Medicine, Botanic
Medicine, Herbal
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Summary:Background. Schistosomiasis is caused by parasitic flatworms and the disease is endemic to most countries in sub-Saharan Africa including Ghana. The current therapeutic agent for managing this disease solely relies on praziquantel. The continual dependence on this single available drug could lead to possible drug resistance. This study seeks to evaluate the antischistosomal activity of the following Ghanaian medicinal plants: Khaya senegalensis, Vernonia amygdalina, Clausena anisata, and Bridelia ferruginea. Methodology. Two concentrations (100 μg/mL and 50 μg/mL) of each extract were tested in a 96-well plate containing 30 newly transformed schistosomula (NTS). Moreover, six worms of both sexes of adult Schistosoma mansoni were exposed to the extracts diluted in the RPMI medium. The assay was performed in a 24-well plate. The parasitic worms were examined using an inverted optical microscope. Results. At 100 μg/mL and 50 μg/mL, all extracts performed better and showed strong activity (p
ISSN:1687-9686
1687-9694
DOI:10.1155/2024/8074291