Sacral Ewing sarcoma with rib, lung, and multifocal skull metastases: A rare case report and review of treatments

Ewing sarcoma (ES) rarely derives from the sacrum or mobile spine. The discovery of primary ES with multimetastatic involvements is exceedingly less frequent in clinical practice. A 23-year-old man with initial primary sacral ES developed metastases of rib, lung, and multifocal skull after receiving...

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Bibliographic Details
Published in:Frontiers in oncology 2022-09, Vol.12
Main Authors: Ye, Chen, Wei, Wei, Tang, Xuebin, Li, Feng, Xin, Baoquan, Chen, Qianqian, Wei, Haifeng, He, Shaohui, Xiao, Jianru
Format: Article
Language:English
Subjects:
decision optimization
en bloc resection
ewing sarcoma
multidisciplinary treatments
multifocal metastases
Oncology
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Summary:Ewing sarcoma (ES) rarely derives from the sacrum or mobile spine. The discovery of primary ES with multimetastatic involvements is exceedingly less frequent in clinical practice. A 23-year-old man with initial primary sacral ES developed metastases of rib, lung, and multifocal skull after receiving surgical intervention and series of adjuvant therapies. We provide this very rare case consisting of its clinical features, imaging findings, treatments, and outcomes. Therapeutic modalities of ES are also reviewed in previous published articles. The prognosis of metastatic ES remains dismal; effective therapeutic modalities for ES require multidisciplinary collaboration, with more high-quality clinical trials to promote the optimal protocols.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.933579