Phenotype and prognostic factors in geriatric and non‐geriatric patients with transthyretin cardiomyopathy

• Published in: ESC Heart Failure 2024-12, Vol.11 (6), p.3814-3832
• Main Authors: Volpentesta, Eugenia, Kharoubi, Mounira, Donadio, Cristiano, Rebiai, Kahina, Fanen, Pascale, Funalot, Benoit, Gendre, Thierry, Audard, Vincent, Canoui‐Poitrine, Florence, Itti, Emmanuel, Teiger, Emmanuel, Planté‐Bordeneuve, Violaine, Oghina, Silvia, Tixier, Denis, Mallet, Sophie, Broussier, Amaury, Damy, Thibaud, Zaroui, Amira
• Format: Article
• Language: English
• Subjects: Age Factors; Age groups; Aged; Aged, 80 and over; Amyloid Neuropathies, Familial - complications; Amyloid Neuropathies, Familial - diagnosis; Amyloid Neuropathies, Familial - genetics; Amyloidosis; ATTR‐CM; Cardiomyopathies - diagnosis; Cardiomyopathies - genetics; Cardiomyopathy; Carpal tunnel syndrome; Ejection fraction; Female; Follow-Up Studies; Genetic testing; Genotype & phenotype; Geriatric; Heart failure; Humans; Male; Medical prognosis; Middle Aged; Mortality; Mutation; Observational; Original; Patients; Phenotype; Population; Prognosis; Prognostic factors; Retrospective Studies; Software; Survival analysis; Survival Rate - trends
• ISSN: 2055-5822; 2055-5822
• DOI: 10.1002/ehf2.14793

Aims Transthyretin cardiac amyloidosis (ATTR‐CM) may be an underestimated cause of heart failure among geriatric patients and represent a unique phenotype and prognostic profile. Methods and results This retrospective, observational, cohort study characterizes cardiac and extracardiac disorders at diagnosis and assesses prognosis among ATTR‐CM patients based on age (geriatric vs. non‐geriatric) and amyloidosis subtype (wild type, ATTRwt and hereditary, ATTRv). In total, 943 patients with ATTR‐CM were included, of which 306 had ATTRv and 637 had ATTRwt. Among these, 331 (35.1%) were non‐geriatric (