Single-nucleus profiling of adult mice sub-ventricular zone after blast-related traumatic brain injury

Explosive blast-related traumatic brain injuries (bTBI) are common in war zones and urban terrorist attacks. These bTBIs often result in complex neuropathologic damage and neurologic complications. However, there is still a lack of specific strategies for diagnosing and/or treating bTBIs. The sub-ve...

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Bibliographic Details
Published in:Scientific data 2023-01, Vol.10 (1), p.13-13, Article 13
Main Authors: Li, Manrui, Chen, Xiameng, Yang, Qiuyun, Cao, Shuqiang, Wyler, Steven, Yuan, Ruixuan, Zhang, Lingxuan, Liao, Miao, Lv, Meili, Wang, Feng, Guo, Yadong, Zhou, Jihong, Zhang, Lin, Xie, Xiaoqi, Liang, Weibo
Format: Article
Language:English
Subjects:
692/420
692/617/375/1345/3190
Aluminum
Animals
Behavior
Blast Injuries - complications
Blast Injuries - pathology
Brain Injuries - complications
Brain Injuries - pathology
Brain Injuries, Traumatic - complications
Data Descriptor
Forensic medicine
Forensic pathology
Forensic sciences
Gene expression
Genomics
Humanities and Social Sciences
Laboratory animals
Medical research
Mice
multidisciplinary
Neurogenesis
Neurological complications
Pathogenesis
Science
Science (multidisciplinary)
snRNA
Terrorism
Traumatic brain injury
Ventricle
Ventricular zone
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Summary:Explosive blast-related traumatic brain injuries (bTBI) are common in war zones and urban terrorist attacks. These bTBIs often result in complex neuropathologic damage and neurologic complications. However, there is still a lack of specific strategies for diagnosing and/or treating bTBIs. The sub-ventricular zone (SVZ), which undergoes adult neurogenesis, is critical for the neurological maintenance and repair after brain injury. However, the cellular responses and mechanisms that trigger and modulate these activities in the pathophysiological processes following bTBI remain poorly understood. Here we employ single-nucleus RNA-sequencing (snRNA-seq) of the SVZ from mice subjected to a bTBI. This data-set, including 15272 cells (7778 bTBI and 7494 control) representing all SVZ cell types and is ideally suited for exploring the mechanisms underlying the pathogenesis of bTBIs. Additionally, it can serve as a reference for future studies regarding the diagnosis and treatment of bTBIs.
ISSN:2052-4463
2052-4463
DOI:10.1038/s41597-022-01925-y