Ovarian Cancer: A Landscape of Mitochondria with Emphasis on Mitochondrial Dynamics

Ovarian cancer (OC) represents the main cause of death from gynecological malignancies in western countries. Altered cellular and mitochondrial metabolism are considered hallmarks in cancer disease. Several mitochondrial aspects have been found altered in OC, such as the oxidative phosphorylation sy...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-01, Vol.24 (2), p.1224
Main Authors: De Rasmo, Domenico, Cormio, Antonella, Cormio, Gennaro, Signorile, Anna
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Bioenergetics
Biosynthesis
Cancer therapies
Cell growth
Chemoresistance
Chemotherapy
Cristae
Cytochrome
Disease
DRP1
Drug resistance
Dynamins - metabolism
Female
Gynecology
Humans
Malignancy
Metabolism
MFN2
Mitochondria
Mitochondria - metabolism
Mitochondrial DNA
Mitochondrial Dynamics
Mitochondrial Membranes - metabolism
Mitochondrial Proteins - metabolism
Mutation
OPA1
Ovarian cancer
Ovarian Neoplasms - metabolism
Oxidative phosphorylation
Oxidative stress
Phosphorylation
Proteins
Respiration
Review
Tumors
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Summary:Ovarian cancer (OC) represents the main cause of death from gynecological malignancies in western countries. Altered cellular and mitochondrial metabolism are considered hallmarks in cancer disease. Several mitochondrial aspects have been found altered in OC, such as the oxidative phosphorylation system, oxidative stress and mitochondrial dynamics. Mitochondrial dynamics includes cristae remodeling, fusion, and fission processes forming a dynamic mitochondrial network. Alteration of mitochondrial dynamics is associated with metabolic change in tumour development and, in particular, the mitochondrial shaping proteins appear also to be responsible for the chemosensitivity and/or chemoresistance in OC. In this review a focus on the mitochondrial dynamics in OC cells is presented.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24021224