Exploration for the opioidergic, GABAergic and histaminergic potentials of synthesized Schiff’s base derivatives: An in-vivo approach

[Display omitted] Herein, five Schiff’s base analogs (designated as AK1 to AK5) were synthesized and screened for their analgesic and anti-inflammatory efficacies. All compounds exhibited analgesic activity at selected doses from 45.31 % to 75.75 %, while the standard drug diclofenac sodium produced...

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Bibliographic Details
Published in:Results in Chemistry 2024-08, Vol.10, p.101716, Article 101716
Main Authors: Khan, Adnan, Khan, Sajjad, Ullah, Zia, Wadood Ali Shah, Syed, Shoaib, Muhammad, Zahoor, Muhammad, Ullah, Riaz, Iqbal, Zafar, Naveed Umar, Muhammad, Ali, Essam A.
Format: Article
Language:English
Subjects:
Inflammation
Mechanism
Pain
Schiff’s base
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Summary:[Display omitted] Herein, five Schiff’s base analogs (designated as AK1 to AK5) were synthesized and screened for their analgesic and anti-inflammatory efficacies. All compounds exhibited analgesic activity at selected doses from 45.31 % to 75.75 %, while the standard drug diclofenac sodium produced result as 86.33 %. Compounds AK1, AK3, AK4 and AK5 were found significantly P
ISSN:2211-7156
2211-7156
DOI:10.1016/j.rechem.2024.101716