Evaluation of the Antiviral Activity of Tabamide A and Its Structural Derivatives against Influenza Virus

Influenza viruses cause severe endemic respiratory infections in both humans and animals worldwide. The emergence of drug-resistant viral strains requires the development of new influenza therapeutics. Tabamide A (TA0), a phenolic compound isolated from tobacco leaves, is known to have antiviral act...

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Published in:International journal of molecular sciences 2023-12, Vol.24 (24), p.17296
Main Authors: Shin, Soo Yong, Lee, Joo Hee, Kim, Jin Woo, Im, Wonkyun Ronny, Damodar, Kongara, Woo, Hyung Ryeol, Kim, Won-Keun, Lee, Jeong Tae, Jeon, Sung Ho
Format: Article
Language:English
Subjects:
antiviral drugs
Apoptosis
HIV
Human immunodeficiency virus
Infections
Influenza
influenza viruses
Protein expression
Proteins
structural derivatives
tabamide A
Tobacco
Viral infections
viral RNA synthesis
Viruses
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Summary:Influenza viruses cause severe endemic respiratory infections in both humans and animals worldwide. The emergence of drug-resistant viral strains requires the development of new influenza therapeutics. Tabamide A (TA0), a phenolic compound isolated from tobacco leaves, is known to have antiviral activity. We investigated whether synthetic TA0 and its derivatives exhibit anti-influenza virus activity. Analysis of structure-activity relationship revealed that two hydroxyl groups and a double bond between C7 and C8 in TA0 are crucial for maintaining its antiviral action. Among its derivatives, TA25 showed seven-fold higher activity than TA0. Administration of TA0 or TA25 effectively increased survival rate and reduced weight loss of virus-infected mice. TA25 appears to act early in the viral infection cycle by inhibiting viral mRNA synthesis on the template-negative strand. Thus, the anti-influenza virus activity of TA0 can be expanded by application of its synthetic derivatives, which may aid in the development of novel antiviral therapeutics.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242417296