Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements

Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause of cancer-related mortality rates worldwide. Although modern research was able to shed light on the pathogenesis of CRC and provide enhanced screening strategies, the prevalence of CRC is still on the rise. St...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-12, Vol.22 (1), p.130
Main Authors: Malki, Ahmed, ElRuz, Rasha Abu, Gupta, Ishita, Allouch, Asma, Vranic, Semir, Al Moustafa, Ala-Eddin
Format: Article
Language:English
Subjects:
Alternations
Angiogenesis
Apoptosis
Cell cycle
chromosomal instability
Chromosomes
Colon
Colon cancer
Colorectal cancer
Colorectal carcinoma
Drug therapy
Kinases
Metastases
Methylation
microsatellite instability
Molecular modelling
molecular pathways
Mutation
NF-κB protein
p53 Protein
Phenotypes
Review
Signal transduction
Smad protein
Stat3 protein
therapeutics
Transcription
Tumors
Vascular endothelial growth factor
Wnt protein
β-Catenin
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Summary:Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause of cancer-related mortality rates worldwide. Although modern research was able to shed light on the pathogenesis of CRC and provide enhanced screening strategies, the prevalence of CRC is still on the rise. Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, analyzing signaling pathways involved in CRC metastasis is necessary to elucidate the underlying mechanism of CRC progression and pharmacotherapy. This review focused on target genes as well as various cellular signaling pathways including Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF, and JAKs/STAT3, which are associated with CRC progression and metastasis. Additionally, alternations in methylation patterns in relation with signaling pathways involved in regulating various cellular mechanisms such as cell cycle, transcription, apoptosis, and angiogenesis as well as invasion and metastasis were also reviewed. To date, understanding the genomic and epigenomic instability has identified candidate biomarkers that are validated for routine clinical use in CRC management. Nevertheless, better understanding of the onset and progression of CRC can aid in the development of early detection molecular markers and risk stratification methods to improve the clinical care of CRC patients.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22010130