Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia

A 72-year-old woman presented with acute onset of double vision, bilateral complete blepharoptosis, and nearly complete ophthalmoplegia. Orbital and brain magnetic resonance imaging were normal. Further investigation revealed bicytopenia with hepatosplenomegaly. Liver biopsy revealed mantle cell lym...

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Bibliographic Details
Published in:Turk oftalmoloji gazetesi 2017-08, Vol.47 (4), p.235-237
Main Authors: Koban, Yaran, Özlece, Hatice, Ayar, Orhan, Koç, Mustafa, Çelik, Hüseyin, Yazar, Zeliha, Burcu, Ayşe
Format: Article
Language:English
Subjects:
Biopsy
blepharoptosis
Bone marrow
Cancer
Care and treatment
Case Report
Case studies
Cellular biology
Chemotherapy
Diagnosis
Eye
Family medical history
Hematology
Lymphoma
Mantle cell lymphoma
Medical imaging
Meningitis
Nervous system
Neurology
NMR
Nuclear magnetic resonance
Oculomotor paralysis
ophthalmoplegia
Paralysis
Patients
Tıp
Tomography
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Summary:A 72-year-old woman presented with acute onset of double vision, bilateral complete blepharoptosis, and nearly complete ophthalmoplegia. Orbital and brain magnetic resonance imaging were normal. Further investigation revealed bicytopenia with hepatosplenomegaly. Liver biopsy revealed mantle cell lymphoma. Cytology later showed the presence of mantle cells in cerebrospinal fluid analysis. Her ophthalmoplegia improved from her first cycle of systemic and intrathecal chemotherapy. To the best of our knowledge, this is the second case in the literature of mantle cell lymphoma with central nervous system involvement presenting with ophthalmoplegia. This symptom should be considered one of the initial signs of mantle cell lymphoma.
ISSN:2149-8695
1300-0659
2147-2661
2149-8709
DOI:10.4274/tjo.80557