Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke

Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment...

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Bibliographic Details
Published in:Stem cell research & therapy 2022-05, Vol.13 (1), p.195-195, Article 195
Main Authors: Zhou, Li, Zhu, Huimin, Bai, Xue, Huang, Jiagui, Chen, Yue, Wen, Jun, Li, Xuemei, Wu, Bowen, Tan, Yongjun, Tian, Mingfen, Ren, Jiangxia, Li, Mengxia, Yang, Qin
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Apoptosis
Bone marrow
Central nervous system
Central nervous system diseases
Chemokines
Clinical trials
Cytokines
Good Manufacturing Practice
Humans
Intravenous administration
Ischemia
Ischemic stroke
Ischemic Stroke - therapy
Kinases
Ligands
Mesenchymal Stem Cell Transplantation
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
Neurogenesis
Neurological diseases
Regenerative medicine
Review
Signal transduction
Stem cell transplantation
Stem cells
Stroke
Stroke - metabolism
Stroke - therapy
Therapeutic applications
Therapeutic targets
Thrombolysis
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Summary:Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment and has been studied in various central nervous system diseases. Animal and clinical studies showed that transplantation of mesenchymal stem cells (MSCs) could alleviate neurological deficits and bring hope for ischemic stroke treatment. This article reviewed biological characteristics, safety, feasibility and efficacy of MSCs therapy, potential therapeutic targets of MSCs, and production process of Good Manufacturing Practices-grade MSCs, to explore the potential therapeutic targets of MSCs in the process of production and use and provide new therapeutic directions for ischemic stroke.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-022-02876-2