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Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke
Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment...
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| Published in: | Stem cell research & therapy 2022-05, Vol.13 (1), p.195-195, Article 195 |
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| container_end_page | 195 |
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| container_title | Stem cell research & therapy |
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| creator | Zhou, Li Zhu, Huimin Bai, Xue Huang, Jiagui Chen, Yue Wen, Jun Li, Xuemei Wu, Bowen Tan, Yongjun Tian, Mingfen Ren, Jiangxia Li, Mengxia Yang, Qin |
| description | Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment and has been studied in various central nervous system diseases. Animal and clinical studies showed that transplantation of mesenchymal stem cells (MSCs) could alleviate neurological deficits and bring hope for ischemic stroke treatment. This article reviewed biological characteristics, safety, feasibility and efficacy of MSCs therapy, potential therapeutic targets of MSCs, and production process of Good Manufacturing Practices-grade MSCs, to explore the potential therapeutic targets of MSCs in the process of production and use and provide new therapeutic directions for ischemic stroke. |
| doi_str_mv | 10.1186/s13287-022-02876-2 |
| format | article |
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Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment and has been studied in various central nervous system diseases. Animal and clinical studies showed that transplantation of mesenchymal stem cells (MSCs) could alleviate neurological deficits and bring hope for ischemic stroke treatment. This article reviewed biological characteristics, safety, feasibility and efficacy of MSCs therapy, potential therapeutic targets of MSCs, and production process of Good Manufacturing Practices-grade MSCs, to explore the potential therapeutic targets of MSCs in the process of production and use and provide new therapeutic directions for ischemic stroke.</description><identifier>ISSN: 1757-6512</identifier><identifier>EISSN: 1757-6512</identifier><identifier>DOI: 10.1186/s13287-022-02876-2</identifier><identifier>PMID: 35551643</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Angiogenesis ; Animals ; Apoptosis ; Bone marrow ; Central nervous system ; Central nervous system diseases ; Chemokines ; Clinical trials ; Cytokines ; Good Manufacturing Practice ; Humans ; Intravenous administration ; Ischemia ; Ischemic stroke ; Ischemic Stroke - therapy ; Kinases ; Ligands ; Mesenchymal Stem Cell Transplantation ; Mesenchymal stem cells ; Mesenchymal Stem Cells - metabolism ; Neurogenesis ; Neurological diseases ; Regenerative medicine ; Review ; Signal transduction ; Stem cell transplantation ; Stem cells ; Stroke ; Stroke - metabolism ; Stroke - therapy ; Therapeutic applications ; Therapeutic targets ; Thrombolysis</subject><ispartof>Stem cell research & therapy, 2022-05, Vol.13 (1), p.195-195, Article 195</ispartof><rights>2022. The Author(s).</rights><rights>2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-2818c42d9cf3d25be6f915fec31c084b584d882466a53b179790cae0e32de6d03</citedby><cites>FETCH-LOGICAL-c496t-2818c42d9cf3d25be6f915fec31c084b584d882466a53b179790cae0e32de6d03</cites><orcidid>0000-0003-4040-1661</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096773/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2666566053?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,38516,43895,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35551643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Li</creatorcontrib><creatorcontrib>Zhu, Huimin</creatorcontrib><creatorcontrib>Bai, Xue</creatorcontrib><creatorcontrib>Huang, Jiagui</creatorcontrib><creatorcontrib>Chen, Yue</creatorcontrib><creatorcontrib>Wen, Jun</creatorcontrib><creatorcontrib>Li, Xuemei</creatorcontrib><creatorcontrib>Wu, Bowen</creatorcontrib><creatorcontrib>Tan, Yongjun</creatorcontrib><creatorcontrib>Tian, Mingfen</creatorcontrib><creatorcontrib>Ren, Jiangxia</creatorcontrib><creatorcontrib>Li, Mengxia</creatorcontrib><creatorcontrib>Yang, Qin</creatorcontrib><title>Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke</title><title>Stem cell research & therapy</title><addtitle>Stem Cell Res Ther</addtitle><description>Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment and has been studied in various central nervous system diseases. Animal and clinical studies showed that transplantation of mesenchymal stem cells (MSCs) could alleviate neurological deficits and bring hope for ischemic stroke treatment. 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metabolism</subject><subject>Neurogenesis</subject><subject>Neurological diseases</subject><subject>Regenerative medicine</subject><subject>Review</subject><subject>Signal transduction</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Stroke</subject><subject>Stroke - metabolism</subject><subject>Stroke - therapy</subject><subject>Therapeutic applications</subject><subject>Therapeutic targets</subject><subject>Thrombolysis</subject><issn>1757-6512</issn><issn>1757-6512</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdks1q3DAUhU1oaUKaF-giGLrpxqn-LW0KJbRNINAukrW4lq_HntrSVJIDeftqMmlIahAW0jkfuodTVR8ouaBUq8-JcqbbhjBWlm5Vw46qE9rKtlGSsjcv9sfVWUpbUj7OCVHiXXXMpZRUCX5STb9CRp8nmOsF3Qh-Skuqwfd1HjHCDtc8uTpD3GBOdRiKKqF348NSHCnjUjuc5zpH8Gk3g8-Qp-DrIcR6Sm7EpbhTjuE3vq_eDjAnPHv6n1Z337_dXl41Nz9_XF9-vWmcMCo3TFPtBOuNG3jPZIdqMFQO6Dh1RItOatFrzYRSIHlHW9Ma4gAJctaj6gk_ra4P3D7A1u7itEB8sAEm-3gQ4sZCLEPNaIWTJaSBKqdAEEoMdE6ynhgtuAE-FNaXA2u3dgv2riQVYX4FfX3jp9Fuwr01xKi25QXw6QkQw58VU7ZLiaUkBh7DmixTSmhSpjFF-vE_6Tas0Zeo9iollSJyD2QHlYshpYjD82Mosfti2EMxbCmGfSyGZcV0_nKMZ8u_GvC_TBa1HQ</recordid><startdate>20220512</startdate><enddate>20220512</enddate><creator>Zhou, Li</creator><creator>Zhu, Huimin</creator><creator>Bai, Xue</creator><creator>Huang, Jiagui</creator><creator>Chen, Yue</creator><creator>Wen, Jun</creator><creator>Li, Xuemei</creator><creator>Wu, Bowen</creator><creator>Tan, Yongjun</creator><creator>Tian, Mingfen</creator><creator>Ren, Jiangxia</creator><creator>Li, Mengxia</creator><creator>Yang, Qin</creator><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4040-1661</orcidid></search><sort><creationdate>20220512</creationdate><title>Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke</title><author>Zhou, Li ; Zhu, Huimin ; Bai, Xue ; Huang, Jiagui ; Chen, Yue ; Wen, Jun ; Li, Xuemei ; Wu, Bowen ; Tan, Yongjun ; Tian, Mingfen ; Ren, Jiangxia ; Li, Mengxia ; Yang, Qin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-2818c42d9cf3d25be6f915fec31c084b584d882466a53b179790cae0e32de6d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Bone marrow</topic><topic>Central nervous system</topic><topic>Central nervous system diseases</topic><topic>Chemokines</topic><topic>Clinical trials</topic><topic>Cytokines</topic><topic>Good Manufacturing Practice</topic><topic>Humans</topic><topic>Intravenous administration</topic><topic>Ischemia</topic><topic>Ischemic stroke</topic><topic>Ischemic Stroke - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Stem cell research & therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Li</au><au>Zhu, Huimin</au><au>Bai, Xue</au><au>Huang, Jiagui</au><au>Chen, Yue</au><au>Wen, Jun</au><au>Li, Xuemei</au><au>Wu, Bowen</au><au>Tan, Yongjun</au><au>Tian, Mingfen</au><au>Ren, Jiangxia</au><au>Li, Mengxia</au><au>Yang, Qin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke</atitle><jtitle>Stem cell research & therapy</jtitle><addtitle>Stem Cell Res Ther</addtitle><date>2022-05-12</date><risdate>2022</risdate><volume>13</volume><issue>1</issue><spage>195</spage><epage>195</epage><pages>195-195</pages><artnum>195</artnum><issn>1757-6512</issn><eissn>1757-6512</eissn><abstract>Ischemic stroke is one of the major causes of death and disability in the world. 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| ispartof | Stem cell research & therapy, 2022-05, Vol.13 (1), p.195-195, Article 195 |
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| language | eng |
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| source | Publicly Available Content Database; PubMed Central; Coronavirus Research Database |
| subjects | Angiogenesis Animals Apoptosis Bone marrow Central nervous system Central nervous system diseases Chemokines Clinical trials Cytokines Good Manufacturing Practice Humans Intravenous administration Ischemia Ischemic stroke Ischemic Stroke - therapy Kinases Ligands Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stem Cells - metabolism Neurogenesis Neurological diseases Regenerative medicine Review Signal transduction Stem cell transplantation Stem cells Stroke Stroke - metabolism Stroke - therapy Therapeutic applications Therapeutic targets Thrombolysis |
| title | Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
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