The PPOS protocol mitigates the detrimental effects of high BMI on embryo and clinical pregnancy outcomes

The impact of high body mass index (BMI) on embryo and pregnancy outcomes in women using the PPOS (progestin-primed ovarian stimulation) protocol during their first frozen embryo transfer (FET) cycles is not clear. This study is to investigate the impact of BMI on oocyte, embryo, and pregnancy outco...

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Bibliographic Details
Published in:Reproductive biology and endocrinology 2024-10, Vol.22 (1), p.124-11, Article 124
Main Authors: Shen, Xi, Li, Menghui, Nie, Yunhan, Si, Jiqiang, Liu, Yali, Wang, Tiantian, Gao, Hongyuan, Lin, Kaibo, Wang, Li
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - epidemiology
Abortion, Spontaneous - etiology
Adult
Affecting factor
Body Mass Index
Clinical outcomes
Cryopreservation - methods
Dosage and administration
Embryo
Embryo Implantation - physiology
Embryo Transfer - methods
Endometrial preparation
Female
Fertilization in Vitro - methods
Health aspects
High BMI
Humans
Live Birth - epidemiology
Methods
Ovulation Induction - adverse effects
Ovulation Induction - methods
Patient outcomes
Physiological aspects
PPOS protocol
Pregnancy
Pregnancy Outcome - epidemiology
Pregnancy Rate
Progestational hormones, Synthetic
Progestins - administration & dosage
Reproductive technology
Retrospective Studies
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Summary:The impact of high body mass index (BMI) on embryo and pregnancy outcomes in women using the PPOS (progestin-primed ovarian stimulation) protocol during their first frozen embryo transfer (FET) cycles is not clear. This study is to investigate the impact of BMI on oocyte, embryo, and pregnancy outcomes in patients who underwent the PPOS protocol. This retrospective study included the first FET cycle of 22,392 patients following the PPOS protocol. The impact of BMI on oocyte and pregnancy outcomes was assessed across different BMI groups, using direct acyclic graph to determine covariates, followed by the application of multiple linear and logistic regressions to further validate this influence. The high BMI groups exhibited a higher number of oocytes; however, no significant differences were observed in good-quality embryos, clinical pregnancy rate, and implantation rate. Nevertheless, the high BMI groups demonstrated a significantly elevated miscarriage rate (9.9% vs. 12.2% vs. 15.7% vs. 18.3%, P 
ISSN:1477-7827
1477-7827
DOI:10.1186/s12958-024-01294-8