Recent advances of sonodynamic therapy in cancer treatment

Sonodynamic therapy （SDT） is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers...

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Bibliographic Details
Published in:Cancer biology & medicine 2016-09, Vol.13 (3), p.325-338
Main Authors: Wan, Guo-Yun, Liu, Yang, Chen, Bo-Wei, Liu, Yuan-Yuan, Wang, Yin-Song, Zhang, Ning
Format: Article
Language:English
Subjects:
cancer
reactive oxygen species
Review
Sonodynamic therapy
sonosensitizer
ultrasound
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Summary:Sonodynamic therapy （SDT） is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. In this article, we critically reviewed the currently accepted mechanisms of sonodynamic action and summarized the classification of sonosensitizers. At the same time, the breath of evidence from SDT-based studies suggests that SDT is promising for cancer treatment.
ISSN:2095-3941
2095-3941
DOI:10.20892/j.issn.2095-3941.2016.0068