Contribution of VEGF polymorphism rs3025020 to short stature and hypertension in elderly Japanese individuals: a cross-sectional study

• Published in: Journal of physiological anthropology 2021-02, Vol.40 (1), p.4-4, Article 4
• Main Authors: Shimizu, Yuji, Yamanashi, Hirotomo, Kawashiri, Shin-Ya, Nobusue, Kenichi, Nonaka, Fumiaki, Noguchi, Yuko, Honda, Yukiko, Arima, Kazuhiko, Abe, Yasuyo, Nagata, Yasuhiro, Maeda, Takahiro
• Format: Article
• Language: English
• Subjects: Age; Aged; Aged, 80 and over; Angiogenesis; Antihypertensives; Blood pressure; Body Height - genetics; Bone marrow; Cardiovascular agents; Cardiovascular diseases; Creatinine; Cross-Sectional Studies; Female; Genetic aspects; Genotype & phenotype; Height; Homozygotes; Humans; Hypertension; Hypertension - epidemiology; Hypertension - genetics; Hypoxia; Japan - epidemiology; Laboratories; Male; Middle Aged; Original; Polymorphism; Polymorphism, Single Nucleotide - genetics; Population; Risk factors; rs3025020; Short stature; Stature, Short; Thermal cycling; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; VEGF
• ISSN: 1880-6805; 1880-6791; 1880-6805
• DOI: 10.1186/s40101-021-00253-1

Recently, short stature has been revealed to be positively associated with hypertension, possibly because this indicates lower activity of vascular maintenance, such as angiogenesis. Vascular endothelial growth factor (VEGF) polymorphism (rs3025020) plays an important role in the progression of angiogenesis and may be associated with both hypertension and hypertension-associated short stature. A cross-sectional study of 1377 elderly Japanese individuals aged 60-89 years was conducted. Short stature was defined as the lowest tertile of height (