Ameliorative Effect of Imperatorin on Dermatophagoides pteronyssinus-Induced Allergic Asthma by Suppressing the Th2 Response in Mice

Imperatorin is a furanocoumarin derivative and an effective ingredient in several Chinese medicinal herbs. It has favorable expectorant, analgesic, and anti-inflammatory effects. In this study, we investigated whether imperatorin has protective effects against Dermatophagoides pteronyssinus (Der p)-...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-10, Vol.27 (20), p.7028
Main Authors: Hsieh, Chia-Chen, Ng, Yan-Yan, Li, Wei-Sung, Tzeng, Chung-Yuh, Hsu, Tsai-Yi, Huang, Wan-Hsiang, Tsai, Jen-Chieh
Format: Article
Language:English
Subjects:
Allergens
Allergies
Alveoli
Analgesics
Animal tissues
Asthma
Bronchus
Chemokines
Cytokines
Dermatophagoides pteronyssinus
Dust
Endothelial cells
Enzyme immunoassay
Herbal medicine
Hyperplasia
Immunoassay
Immunoglobulin E
Immunoglobulin G
imperatorin
Inflammation
Interferon
Interleukin 10
Interleukin 12
Interleukin 13
Interleukin 5
Lavage
Leukocytes (eosinophilic)
Lungs
Lymphocytes
Lymphocytes T
Medicinal herbs
Th2 response
γ-Interferon
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Summary:Imperatorin is a furanocoumarin derivative and an effective ingredient in several Chinese medicinal herbs. It has favorable expectorant, analgesic, and anti-inflammatory effects. In this study, we investigated whether imperatorin has protective effects against Dermatophagoides pteronyssinus (Der p)-induced asthma in mice. Lung and bronchial tissues were histopathologically examined through hematoxylin–eosin staining. The concentrations of immunoglobin E (IgE), IgG1, IgG2a in serum and those of T helper 1 (Th1) and two cytokines and eosinophil-activated chemokines in bronchoalveolar lavage fluid (BALF) were detected using an enzyme immunoassay. Histological examination revealed that imperatorin reduced inflammatory cell infiltration, mucus hypersecretion, and endothelial cell hyperplasia. The examination also indicated that imperatorin could reduce the inflammatory cell count in BALF as well as IgE and IgG1 expression in serum, but IgG2a expression was significantly increased. Imperatorin reduced the production of interleukin (IL)-4, IL-5, and IL-13 by Th2, promoted the production of interferon-γ and IL-12 by Th1, and increased the production of IL-10 in bronchoalveolar lavage fluid. These findings suggest that imperatorin has a considerable anti-inflammatory effect on Der p-induced allergic asthma in mice.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27207028