Amikacin pharmacokinetic/pharmacodynamic in intensive care unit: a prospective database

• Published in: Annals of intensive care 2020-06, Vol.10 (1), p.75-75, Article 75
• Main Authors: Logre, Elsa, Enser, Maya, Tanaka, Sébastien, Dubert, Marie, Claudinon, Aurore, Grall, Nathalie, Mentec, Hervé, Montravers, Philippe, Pajot, Olivier
• Format: Article
• Language: English
• Subjects: Amikacin; Anesthesiology; Critical Care Medicine; Emergency Medicine; Infections; Intensive; Intensive care; Intensive care unit; Life Sciences; Medicine; Medicine & Public Health; Pharmacodynamic; Pharmacodynamics; Pharmacokinetic; Pharmacokinetics
• ISSN: 2110-5820; 2110-5820
• DOI: 10.1186/s13613-020-00685-5

Background Aminoglycosides have a concentration-dependent therapeutic effect when peak serum concentration ( C max ) reaches eight to tenfold the minimal inhibitory concentration (MIC). With an amikacin MIC of 8 mg/L, the C max should be 64–80 mg/L. This objective is based on clinical breakpoints and not on measured MIC. This study aimed to assess the proportion of patients achieving the pharmacokinetic/pharmacodynamic (PK/PD) target C max /MIC ≥ 8 using the measured MIC in critically ill patients treated for documented Gram-negative bacilli (GNB) infections. Methods Retrospective analysis from February 2016 to December 2017 of a prospective database conducted in 2 intensive care units (ICU). All patients with documented severe GNB infections treated with amikacin (single daily dose of 25 mg/kg of total body weight (TBW)) with both MIC and C max measurements at first day of treatment (D1) were included. Results are expressed in n (%) or median [min–max]. Results 93 patients with 98 GNB-documented infections were included. The median C max was 55.2 mg/L [12.2–165.7] and the median MIC was 2 mg/L [0.19–16]. C max /MIC ratio ≥ 8 was achieved in 87 patients (88.8%) while a C max  ≥ 64 mg/L was achieved in only 38 patients (38.7%). Overall probability of PK/PD target attainment was 93%. No correlation was found between C max /MIC ratio and clinical outcome at D8 and D28. Conclusion According to PK/PD parameters observed in our study, single daily dose of amikacin 25 mg/kg of TBW appears to be sufficient in most critically ill patients treated for severe GNB infections.