Development of Phenothiazine Hybrids with Potential Medicinal Interest: A Review

The molecular hybridization approach has been used to develop compounds with improved efficacy by combining two or more pharmacophores of bioactive scaffolds. In this context, hybridization of various relevant pharmacophores with phenothiazine derivatives has resulted in pertinent compounds with div...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-01, Vol.27 (1), p.276
Main Authors: Posso, Marina C, Domingues, Fernanda C, Ferreira, Susana, Silvestre, Samuel
Format: Article
Language:English
Subjects:
Alzheimer's disease
Analgesics
Animals
anti-Alzheimer
Antihistamines
Antimalarial agents
antimicrobial
Antimicrobial agents
Antipsychotics
antitumor
Apoptosis
Binding sites
Biological activity
Breast cancer
Cancer therapies
Cell cycle
Cell division
Cell growth
Cytotoxicity
Drug Development
Drug resistance
Fungicides
Humans
Hybridization
Hybrids
Inflammation
molecular hybridization
Multidrug resistance
Pharmacology
pharmacophore
Pharmacophores
Phenothiazine
Phenothiazines - chemical synthesis
Phenothiazines - chemistry
Phenothiazines - therapeutic use
Review
Structure-Activity Relationship
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Description
Summary:The molecular hybridization approach has been used to develop compounds with improved efficacy by combining two or more pharmacophores of bioactive scaffolds. In this context, hybridization of various relevant pharmacophores with phenothiazine derivatives has resulted in pertinent compounds with diverse biological activities, interacting with specific or multiple targets. In fact, the development of new drugs or drug candidates based on phenothiazine system has been a promising approach due to the diverse activities associated with this tricyclic system, traditionally present in compounds with antipsychotic, antihistaminic and antimuscarinic effects. Actually, the pharmacological actions of phenothiazine hybrids include promising antibacterial, antifungal, anticancer, anti-inflammatory, antimalarial, analgesic and multi-drug resistance reversal properties. The present review summarizes the progress in the development of phenothiazine hybrids and their biological activity.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27010276