Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod

Urp1 and Urp2 are two neuropeptides of the urotensin II family identified in teleost fish and mainly expressed in cerebrospinal fluid (CSF)-contacting neurons. It has been recently proposed that Urp1 and Urp2 are required for correct axis formation and maintenance. Their action is thought to be medi...

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Published in:Open biology 2021-08, Vol.11 (8), p.210065-210065
Main Authors: Alejevski, Faredin, Leemans, Michelle, Gaillard, Anne-Laure, Leistenschneider, David, de Flori, Céline, Bougerol, Marion, Le Mével, Sébastien, Herrel, Anthony, Fini, Jean-Baptiste, Pézeron, Guillaume, Tostivint, Hervé
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
cerebrospinal fluid-contacting neurons
Gene Expression Profiling
Gene Expression Regulation, Developmental
Life Sciences
muscles
Phylogeny
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - metabolism
scoliosis
Sequence Homology
Somatotypes
spinal cord
urotensin II
Urotensins - metabolism
Xenopus
Xenopus laevis
Xenopus Proteins - genetics
Xenopus Proteins - metabolism
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Summary:Urp1 and Urp2 are two neuropeptides of the urotensin II family identified in teleost fish and mainly expressed in cerebrospinal fluid (CSF)-contacting neurons. It has been recently proposed that Urp1 and Urp2 are required for correct axis formation and maintenance. Their action is thought to be mediated by the receptor Uts2r3, which is specifically expressed in dorsal somites. In support of this view, it has been demonstrated that the loss of results in severe scoliosis in adult zebrafish. In the present study, we report for the first time the occurrence of but not of , in two tetrapod species of the genus. In , we show that mRNA-containing cells are CSF-contacting neurons. Furthermore, we identified the counterparts of zebrafish and we demonstrate that, as in zebrafish, it is expressed in the dorsal somatic musculature. Finally, we reveal that, in the disruption of results in an abnormal curvature of the antero-posterior axis of the tadpoles. Taken together, our results suggest that the role of the Utr4 signalling pathway in the control of body straightness is an ancestral feature of bony vertebrates and not just a peculiarity of ray-finned fishes.
ISSN:2046-2441
2046-2441
DOI:10.1098/rsob.210065