Pregnancy and live birth after follicle-stimulating hormone treatment for an infertile couple including a male affected by Sertoli cell-only syndrome

In males with nonobstructive azoospermia, one of the main histopathologic patterns of the testis is Sertoli cell-only syndrome (SCOS), in which no germ cells are present and only Sertoli cells are contained in the seminiferous tubules. There is not any formal treatment for this pathological conditio...

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Bibliographic Details
Published in:Research and reports in urology 2017-01, Vol.9, p.203-208
Main Authors: Paulis, Gianni, Paulis, Luca, Romano, Gennaro, Concas, Carmen, Di Sarno, Marika, Pagano, Renata, Di Filippo, Antonio, Di Petrillo, Maria Luisa
Format: Article
Language:English
Subjects:
Azoospermia
Case Report
Consent
Cystic fibrosis
Family medical history
FSH
Genetic engineering
ICSI
Infertility
live birth pregnancy
Patients
Polycystic ovary syndrome
sertoli cell-only syndrome
Sperm
Spermatogenesis
TESE sperm retrieval
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Summary:In males with nonobstructive azoospermia, one of the main histopathologic patterns of the testis is Sertoli cell-only syndrome (SCOS), in which no germ cells are present and only Sertoli cells are contained in the seminiferous tubules. There is not any formal treatment for this pathological condition. However, several studies reported the possibility to perform testicular sperm extraction in patients with SCOS, although, according to some authors, sperm retrieval is possible only in the presence of focal spermatogenesis. We report the case of an infertile couple in whom the 30-year-old male was azoospermic. After the diagnosis, the patient underwent multiple bilateral testicular biopsies, which showed a histological pattern corresponding to SCOS. We administered a cycle of hormone stimulation followed by medically assisted procreation procedures to the male patient. Therefore, the male patient was treated with follicle-stimulating hormone gonadotropin for a total of 7 months (150 IU recombinant human follicle stimulating hormone three times per week). After carrying out a new multiple testicular sperm extraction, several spermatozoa were microscopically observed, and it was then possible to perform an intracytoplasmic sperm injection with subsequent embryo transfer of the blastocyst into the wife's uterus, and so pregnancy was established and developed. Subsequently, the pregnancy resulted in the live birth of a girl.
ISSN:2253-2447
2253-2447
DOI:10.2147/RRU.S148071