Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale

In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated...

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Bibliographic Details
Published in:Mediators of Inflammation 2015-01, Vol.2015 (2015), p.395-401-236
Main Authors: Menon, Tiziano, Faggian, Giuseppe, Salvetti, Beatrice, Montresor, Alessio, Milani, Elisabetta, Linardi, Daniele, Solani, Erika, Stranieri, Chiara, Tessari, Maddalena, Rungatscher, Alessio, Merigo, Flavia
Format: Article
Language:English
Subjects:
Animals
Blood
Carotid arteries
Circulation, Artificial
Extracorporeal Circulation
Health aspects
Heart surgery
Inflammation
Inflammation - metabolism
Laboratories
Leukocytes
Leukocytes - metabolism
Models, Animal
Oxygenators
Oxygenators, Membrane
Rodents
Studies
Surgical apparatus & instruments
Veins & arteries
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Summary:In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated fundamental information on the role of oxygenator of ECC in activating inflammatory signaling pathways on leukocytes, leading to systemic inflammatory response, and organ dysfunction. The present results suggest that experimental animal models of ECC used in translational research on inflammatory response should be based on standardized, reproducible oxygenators with clinical characteristics.
ISSN:0962-9351
1466-1861
DOI:10.1155/2015/484979