Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans

The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions...

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Bibliographic Details
Published in:Brazilian Journal of Pharmaceutical Sciences 2020-01, Vol.56
Main Authors: Rocha, Letícia Fernandes da, Pippi, Bruna, Fuentefria, Alexandre Meneghello, Mezzari, Adelina
Format: Article
Language:English
Subjects:
Antifungal agents
Cryptococcus neoformans
Experiments
Fluconazole
Fungal infections
Ibuprofen
Itraconazole
Nonsteroidal anti-inflammatory drugs
PHARMACOLOGY & PHARMACY
Synergism
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Summary:The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were evaluated using checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis.
ISSN:2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902019000318599