Extracorporeal cytokine adsorption as an alternative to pharmacological inhibition of IL-6 in COVID-19

A major advantage of extracorporeal cytokine adsorption over the other therapeutic approaches discussed in this debate is that it does not selectively block a specific receptor or signal transduction cascade, but it rather reduces particularly elevated concentrations of various inflammatory mediator...

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Bibliographic Details
Published in:Critical care (London, England) England), 2020-08, Vol.24 (1), p.514-2, Article 514
Main Authors: Supady, Alexander, Duerschmied, Daniel, Bode, Christoph, Rieder, Marina, Lother, Achim
Format: Article
Language:English
Subjects:
Adsorption
Adult respiratory distress syndrome
Betacoronavirus
Cardiology
Clinical trials
Coronavirus Infections
Coronaviruses
COVID-19
Critical care
Cytokines
Heart surgery
Humans
Interleukin-6
Interleukins
Letter
Pandemics
Pneumonia
Pneumonia, Viral
Respiratory Distress Syndrome
SARS-CoV-2
Signal transduction
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Summary:A major advantage of extracorporeal cytokine adsorption over the other therapeutic approaches discussed in this debate is that it does not selectively block a specific receptor or signal transduction cascade, but it rather reduces particularly elevated concentrations of various inflammatory mediators such as interleukins, TNF-α, and also interferons; these factors have both pro- and anti-inflammatory functions. [...]we recommend a cautious approach to intervention or “modulation” in the immune response in COVID-19 patients as long as the pathophysiological background remains to be unveiled. Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
ISSN:1364-8535
1466-609X
1364-8535
1366-609X
DOI:10.1186/s13054-020-03238-1