Marine drugs for cancer: surfacing biotechnological innovations from the oceans

This review will discuss the contributions of marine natural molecules, a source only recently found to have pharmaceutical prospects, to the development of anticancer drugs. Of the seven clinically utilized compounds with a marine origin, four are used for the treatment of cancer. The development o...

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Bibliographic Details
Published in:Clinics (São Paulo, Brazil) Brazil), 2018-01, Vol.73 (suppl 1), p.e482s, Article e482s
Main Authors: Jimenez, Paula Christine, Wilke, Diego Veras, Costa-Lotufo, Leticia Veras
Format: Article
Language:English
Subjects:
Anti-tubulin Drugs
Antibody-Drug Conjugates
Anticancer Drug Development
Antimetabolites Drugs
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Aquatic Organisms - chemistry
Biotechnology - methods
Cytarabine - chemistry
DNA-Alkylating Agents
Drug Development - methods
Drug Discovery
Furans - chemistry
Immunoconjugates - chemistry
Immunoconjugates - pharmacology
Immunoconjugates - therapeutic use
Ketones - chemistry
Marine Biotechnology
MEDICINE, GENERAL & INTERNAL
Neoplasms - drug therapy
Oceans and Seas
Review ARTICLE
Trabectedin - chemistry
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Summary:This review will discuss the contributions of marine natural molecules, a source only recently found to have pharmaceutical prospects, to the development of anticancer drugs. Of the seven clinically utilized compounds with a marine origin, four are used for the treatment of cancer. The development of these drugs has afforded valuable knowledge and crucial insights to meet the most common challenges in this endeavor, such as toxicity and supply. In this context, the development of these compounds will be discussed herein to illustrate, with successful examples provided by cytarabine, trabectedin, eribulin and brentuximab vedotin, the steps involved in this process as well as the scientific advances and technological innovation potential associated with developing a new drug from marine resources.
ISSN:1807-5932
1980-5322
1980-5322
DOI:10.6061/clinics/2018/e482s