Trifluoperazine and Its Analog Suppressed the Tumorigenicity of Non-Small Cell Lung Cancer Cell; Applicability of Antipsychotic Drugs to Lung Cancer Treatment

Despite significant advances in diagnostic and therapeutic technologies, lung cancer remains the leading cause of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases. Recently, some antipsychotics have been shown to possess antic...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicines 2022-04, Vol.10 (5), p.1046
Main Authors: Jeong, Joo Yeon, Park, Haangik, Yoo, Hong, Kim, Eun-Jin, Jeon, Borami, Lee, Jong Deog, Kang, Dawon, Lee, Changjoon Justin, Paek, Sun Ha, Roh, Eun Joo, Yi, Gwan-Su, Kang, Sang Soo
Format: Article
Language:English
Subjects:
Antipsychotics
Antitumor activity
Apoptosis
Cancer therapies
Cell growth
Cell migration
Cell proliferation
Chemotherapy
Colonies
Datasets
DNA fragmentation
Flow cytometry
Gene expression
Kinases
Lung cancer
Metastases
non-small cell lung cancer
Non-small cell lung carcinoma
Ontology
Patients
proliferation
Psychotropic drugs
Schizophrenia
Small cell lung carcinoma
Survival analysis
Therapeutic applications
Trifluoperazine
Tumorigenicity
Xenografts
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite significant advances in diagnostic and therapeutic technologies, lung cancer remains the leading cause of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases. Recently, some antipsychotics have been shown to possess anticancer activity. However, the effects of antipsychotics on NSCLC need to be further explored. We examined the effects of trifluoperazine (TFP), a commonly used antipsychotic drug, and its synthetic analogs on A549 human lung cancer cells. In addition, cell proliferation analysis, colony formation assay, flow cytometry, western blot analysis, and in vivo xenograft experiments were performed. Key genes and mechanisms possibly affected by TFP are significantly related to better survival outcomes in lung cancer patients. Treatment with TFP and a selected TFP analog 3dc significantly inhibited the proliferation, anchorage-dependent/independent colony formation, and migration of A549 cells. Treatment with 3dc affected the expression of genes related to the apoptosis and survival of A549 cells. Treatment with 3dc promoted apoptosis and DNA fragmentation. In all experiments, including in vivo studies of metastatic lung cancer development, 3dc had more substantial anticancer effects than TFP. According to our analysis of publicly available clinical data and in vitro and in vivo experiments, we suggest that some kinds of antipsychotics prevent the progression of NSCLC. Furthermore, this study indicates a synthetic TFP analog that could be a potential therapeutic for lung cancer.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10051046