Merkel Cell Carcinoma with Lymphoepithelioma-Like Pattern : A Case Report of an Exceedingly Rare Variant of Merkel Cell Carcinoma with Lymph Node Metastases at Presentation

Merkel cell carcinoma (MCC) or primary neuroendocrine carcinoma of the skin is a rare neoplasm with aggressive behavior. Primary lymphoepithelioma-like (LEL) carcinoma of the skin is a recently described exceptional tumor, with a relatively good prognosis, and is characterized by a neoplastic epithe...

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Bibliographic Details
Published in:Case reports in pathology 2011-01, Vol.2011 (2011), p.1-4
Main Authors: Ben Abdelkarim, Soumaya, Dhouibi, Abdelmajid, Moussa, Adnène, Hadhri, Rim, Njim, Leila, Mighri, Khalifa, Zakhama, Abdelfatteh
Format: Article
Language:English
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Case Report
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Summary:Merkel cell carcinoma (MCC) or primary neuroendocrine carcinoma of the skin is a rare neoplasm with aggressive behavior. Primary lymphoepithelioma-like (LEL) carcinoma of the skin is a recently described exceptional tumor, with a relatively good prognosis, and is characterized by a neoplastic epithelial component associated with a dense lymphoid stroma. Rarely, MCC shows a marked lymphocytic host response or can even mimic a LEL carcinoma. We report a new case of MCC mimicking an LEL carcinoma in a 72-year-old male; the diagnosis of MCC was made on the basis of the morphology and immunohistochemical findings. We present through this case an exceptional pattern of MCC which can be misleading, and we insist on differential diagnoses.
ISSN:2090-6781
2090-679X
DOI:10.1155/2011/840575