Copeptin levels increase in response to both insulin-induced hypoglycemia and arginine but not to clonidine: data from GH-stimulation tests

Background The diagnosis of the polyuria–polydipsia syndrome is challenging. Copeptin is a robust biomarker of arginine vasopressin (AVP) secretion. Arginine, which stimulates growth hormone (GH), has been shown also to stimulate copeptin secretion via unknown mechanisms. Aim The aim was to investig...

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Bibliographic Details
Published in:Endocrine Connections 2023-11, Vol.12 (11), p.1-7
Main Authors: Stankovic, Jelena, Kristensen, Kurt, Birkebæk, Niels, Jørgensen, Jens Otto Lunde, Søndergaard, Esben
Format: Article
Language:English
Subjects:
arginine
clonidine
copeptin
insulin tolerance test
pituitary
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Summary:Background The diagnosis of the polyuria–polydipsia syndrome is challenging. Copeptin is a robust biomarker of arginine vasopressin (AVP) secretion. Arginine, which stimulates growth hormone (GH), has been shown also to stimulate copeptin secretion via unknown mechanisms. Aim The aim was to investigate copeptin levels in response to three different GH stimulation tests in patients suspected of GH deficiency. Methods In this cross-sectional study, we measured plasma copeptin levels at baseline and at 60, 105, and 150 min in patients undergoing a stimulation test for growth hormone deficiency with either arginine (n = 16), clonidine (n = 8) or the insulin tolerance test (ITT) (n = 10). Results In patients undergoing the arginine test, the mean age was 9 years, and 10 years for clonidine. The ITT was only performed in adult patients (>18 years) with a mean age of 49 years. Copeptin level increased significantly from baseline to 60 min after arginine (P
ISSN:2049-3614
2049-3614
DOI:10.1530/EC-23-0042