Follicular Proinflammatory Cytokines and Chemokines as Markers of IVF Success

Cytokines are key modulators of the immune system and also contribute to regulation of the ovarian cycle. In this study, Bender MedSystems FlowCytomix technology was used to analyze follicular cytokines (proinflammatory: IL-1β, IL-6, IL-18, IFN-γ, IFN-α, TNF-α, IL-12, and IL-23;, and anti-inflammato...

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Bibliographic Details
Published in:Clinical & developmental immunology 2012-01, Vol.2012 (2012), p.1-10
Main Authors: Sarapik, Aili, Velthut, Agne, Haller-Kikkatalo, Kadri, Faure, Gilbert C., Béné, Marie-Christine, de Carvalho Bittencourt, Marcelo, Massin, Frédéric, Uibo, Raivo, Salumets, Andres
Format: Article
Language:English
Subjects:
Adult
Biomarkers - metabolism
Clinical Study
Cytokines - genetics
Cytokines - immunology
Cytokines - metabolism
Embryonic Development - genetics
Female
Fertilization in Vitro
Granulosa Cells - immunology
Granulosa Cells - metabolism
Granulosa Cells - pathology
High-Throughput Screening Assays
Humans
Infertility, Female - diagnosis
Infertility, Female - pathology
Infertility, Female - physiopathology
Infertility, Female - therapy
Inflammation Mediators - metabolism
Ovarian Follicle - pathology
Pregnancy
Prognosis
Treatment Outcome
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Summary:Cytokines are key modulators of the immune system and also contribute to regulation of the ovarian cycle. In this study, Bender MedSystems FlowCytomix technology was used to analyze follicular cytokines (proinflammatory: IL-1β, IL-6, IL-18, IFN-γ, IFN-α, TNF-α, IL-12, and IL-23;, and anti-inflammatory: G-CSF), chemokines (MIP-1α, MIP-1β, MCP-1, RANTES, and IL-8), and other biomarkers (sAPO-1/Fas, CD44(v6)) in 153 women undergoing in vitro fertilization (IVF). Cytokine origin was studied by mRNA analysis of granulosa cells. Higher follicular MIP-1α and CD44(v6) were found to correlate with polycystic ovary syndrome, IL-23, INF-γ, and TNF-α with endometriosis, higher CD44(v6) but lower IL-β and INF-α correlated with tubal factor infertility, and lower levels of IL-18 and CD44(v6) characterized unexplained infertility. IL-12 positively correlated with oocyte fertilization and embryo development, while increased IL-18, IL-8, and MIP-1β were associated with successful IVF-induced pregnancy.
ISSN:1740-2522
1740-2530
DOI:10.1155/2012/606459