Visual evoked potentials show strong positive association with intracranial pressure in patients with cryptococcal meningitis

To verify the relationship between intracranial pressure and flash visual evoked potentials (F-VEP) in patients with cryptococcal meningitis. Method The sample included adults diagnosed with cryptococcal meningitis admitted at a reference hospital for infectious diseases. The patients were subjected...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2015-04, Vol.73 (4), p.309-313
Main Authors: Vieira, Marcelo Adriano da Cunha Silva, Cavalcanti, Maria do Amparo Salmito, Costa, Dorcas Lamounier, Eulálio, Kelsen Dantas, Vale, Otoni Cardoso do, Vieira, Chrystiany Placido de Brito, Costa, Carlos Henrique Nery
Format: Article
Language:English
Subjects:
Adult
Cerebrospinal Fluid Leak - physiopathology
Cerebrospinal Fluid Pressure - physiology
Cryptococcus
Evoked Potentials, Visual - physiology
Female
Humans
Intracranial Hypertension - etiology
Intracranial Hypertension - physiopathology
Intracranial Pressure - physiology
Male
meningite criptocócica
Meningitis, Cryptococcal - complications
Meningitis, Cryptococcal - physiopathology
Middle Aged
NEUROSCIENCES
Photic Stimulation - methods
potenciais evocados visuais
pressão intracraniana
PSYCHIATRY
Reference Values
Regression Analysis
Spinal Puncture
Time Factors
Young Adult
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Summary:To verify the relationship between intracranial pressure and flash visual evoked potentials (F-VEP) in patients with cryptococcal meningitis. Method The sample included adults diagnosed with cryptococcal meningitis admitted at a reference hospital for infectious diseases. The patients were subjected to F-VEP tests shortly before lumbar puncture. The Pearson’s linear correlation coefficient was calculated and the linear regression analysis was performed. Eighteen individuals were subjected to a total of 69 lumbar punctures preceded by F-VEP tests. At the first lumbar puncture performed in each patient, N2 latency exhibited a strong positive correlation with intracranial pressure (r = 0.83; CI = 0.60 - 0.94; p < 0.0001). The direction of this relationship was maintained in subsequent punctures. The intracranial pressure measured by spinal tap manometry showed strong positive association with the N2 latency F-VEP in patients with cryptococcal meningitis.
ISSN:0004-282X
1678-4227
1678-4227
0004-282X
DOI:10.1590/0004-282X20150002