Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection and the molecular characteristics of MRSA bacteraemia over a two-year period in a tertiary teaching hospital in Malaysia

Methicillin-resistant Staphylococcus aureus (MRSA) is an established pathogen that causes hospital- and community-acquired infections worldwide. The prevalence rate of MRSA infections were reported to be the highest in Asia. As there is limited epidemiological study being done in Malaysia, this stud...

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Bibliographic Details
Published in:BMC infectious diseases 2017-04, Vol.17 (1), p.274-274, Article 274
Main Authors: Sit, Pik San, Teh, Cindy Shuan Ju, Idris, Nuryana, Sam, I-Ching, Syed Omar, Sharifah Faridah, Sulaiman, Helmi, Thong, Kwai Lin, Kamarulzaman, Adeeba, Ponnampalavanar, Sasheela
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bacteremia
Bacteremia - epidemiology
Bacteremia - microbiology
Bacterial Typing Techniques
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Cross Infection - epidemiology
Data processing
Demographics
Diabetes mellitus
Drug resistance
Epidemiology
Female
Food processing industry
Gel electrophoresis
Gram-positive bacteria
Health risks
Hospitals, Teaching
Humans
Hypertension
Infectious diseases
Kidney transplantation
Leukocidin
Malaysia - epidemiology
Male
Methicillin
Methicillin-resistant Staphylococcus aureus (MRSA)
Methicillin-Resistant Staphylococcus aureus - genetics
Middle Aged
Minimum inhibitory concentration
MLST
MRSA Bacteraemia
Multilocus Sequence Typing
Pathogens
PFGE
Prevalence
Pulsed-field gel electrophoresis
SCCmec types
Skin diseases
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus infections
Statistical analysis
Tertiary Care Centers
Vancomycin
Young Adult
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Summary:Methicillin-resistant Staphylococcus aureus (MRSA) is an established pathogen that causes hospital- and community-acquired infections worldwide. The prevalence rate of MRSA infections were reported to be the highest in Asia. As there is limited epidemiological study being done in Malaysia, this study aimed to determine the prevalence of MRSA infection and the molecular characteristics of MRSA bacteraemia. Two hundred and nine MRSA strains from year 2011 to 2012 were collected from a tertiary teaching hospital in Malaysia. The strains were characterized by antimicrobial susceptibility testing, staphylococcal cassette chromosome mec (SCCmec) typing, detection of Panton-Valentine leukocidin (PVL) gene, multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). Patient's demographic and clinical data were collected and correlated with molecular data by statistical analysis. Male gender and patient >50 years of age (p 
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-017-2384-y